Exploring the polarization of M1 and M2 macrophages in the context of skin diseases

被引：12
作者：
Apeku, Ernestina [1 ,2 ]
Tantuoyir, Marcarious M. [3 ]
Zheng, Rui [1 ]
Tanye, Nestor [4 ]
机构：
[1] Shanxi Med Univ, Hosp 1, Dept Dermatol, Taiyuan, Shanxi, Peoples R China
[2] Shanxi Med Univ, Grad Dept, Taiyuan, Shanxi, Peoples R China
[3] Univ Tehran Med Sci, Sch Med, Tehran, Iran
[4] Xi An Jiao Tong Univ, Sch Automat Sci & Engn, Xian, Peoples R China
来源：
MOLECULAR BIOLOGY REPORTS | 2024年 / 51卷 / 01期
关键词：
M1; macrophage; M2; Polarization; Immune regulation; Skin diseases; ACTIVATION; HEALTH; CELLS; PENTOXIFYLLINE; PSORIASIS; CYTOKINES;
D O I：
10.1007/s11033-023-09014-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Macrophages are critical components of the immune system and play vital roles in pathogen defense, immune regulation, and tissue repair. These cells exhibit different polarization states depending on environmental signals, and the M1/M2 paradigm is a useful tool for comprehending these states. This review article comprehensively presents the underlying mechanisms of M1 and M2 macrophage polarization and examines their polarization in various skin diseases. Additionally, this paper discusses therapeutic strategies that target M1 and M2 macrophage polarization in skin diseases. A more profound understanding of macrophage polarization in skin diseases could provide valuable insights for the development of innovative therapeutic strategies.
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页数：9
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