Exploring the polarization of M1 and M2 macrophages in the context of skin diseases

被引：8
作者：
Apeku, Ernestina [1 ,2 ]
Tantuoyir, Marcarious M. [3 ]
Zheng, Rui [1 ]
Tanye, Nestor [4 ]
机构：
[1] Shanxi Med Univ, Hosp 1, Dept Dermatol, Taiyuan, Shanxi, Peoples R China
[2] Shanxi Med Univ, Grad Dept, Taiyuan, Shanxi, Peoples R China
[3] Univ Tehran Med Sci, Sch Med, Tehran, Iran
[4] Xi An Jiao Tong Univ, Sch Automat Sci & Engn, Xian, Peoples R China
来源：
MOLECULAR BIOLOGY REPORTS | 2024年 / 51卷 / 01期
关键词：
M1; macrophage; M2; Polarization; Immune regulation; Skin diseases; ACTIVATION; HEALTH; CELLS; PENTOXIFYLLINE; PSORIASIS; CYTOKINES;
D O I：
10.1007/s11033-023-09014-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Macrophages are critical components of the immune system and play vital roles in pathogen defense, immune regulation, and tissue repair. These cells exhibit different polarization states depending on environmental signals, and the M1/M2 paradigm is a useful tool for comprehending these states. This review article comprehensively presents the underlying mechanisms of M1 and M2 macrophage polarization and examines their polarization in various skin diseases. Additionally, this paper discusses therapeutic strategies that target M1 and M2 macrophage polarization in skin diseases. A more profound understanding of macrophage polarization in skin diseases could provide valuable insights for the development of innovative therapeutic strategies.
引用
收藏
页数：9
相关论文
共 79 条
  • [1] Impact of prebiotics and probiotics on skin health
    Al-Ghazzewi, F. H.
    Tester, R. F.
    [J]. BENEFICIAL MICROBES, 2014, 5 (02) : 99 - 107
  • [2] Anaya J.M., 2013, Autoimmunity: From Bench to Bedside
  • [3] Systematic Review and Recommendations to Combine Newer Therapies With Conventional Therapy in Psoriatic Disease
    Arora, Sandeep
    Das, Pankaj
    Arora, Gulhima
    [J]. FRONTIERS IN MEDICINE, 2021, 8
  • [4] Macrophages: Their role, activation and polarization in pulmonary diseases
    Arora, Shweta
    Dev, Kapil
    Agarwal, Beamon
    Das, Pragnya
    Syed, Mansoor Ali
    [J]. IMMUNOBIOLOGY, 2018, 223 (4-5) : 383 - 396
  • [5] Role of Human Macrophage Polarization in Inflammation during Infectious Diseases
    Atri, Chiraz
    Guerfali, Fatma Z.
    Laouini, Dhafer
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (06):
  • [6] Barbosa JN., 2020, Handbook of biomaterials biocompatibility
  • [7] Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders
    Baswan, Sudhir M.
    Klosner, Allison E.
    Glynn, Kelly
    Rajgopal, Arun
    Malik, Kausar
    Yim, Sunghan
    Stern, Nathan
    [J]. CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY, 2020, 13 : 927 - 942
  • [8] Vitamin D status in Psoriasis: impact and clinical correlations
    Bhat, Ghulam Hassan
    Guldin, Sadaf
    Khan, Mosin Saleem
    Yasir, Mir
    Prasad, Ganesh
    [J]. BMC NUTRITION, 2022, 8 (01)
  • [9] Dendritic cells and cytokines in human inflammatory and autoimmune diseases
    Blanco, Patrick
    Palucka, A. Karolina
    Pascual, Virginia
    Banchereau, Jacques
    [J]. CYTOKINE & GROWTH FACTOR REVIEWS, 2008, 19 (01) : 41 - 52
  • [10] Macrophages During the Fibrotic Process: M2 as Friend and Foe
    Braga, Tarcio Teodoro
    Agudelo, Juan Sebastian Henao
    Camara, Niels Olsen Saraiva
    [J]. FRONTIERS IN IMMUNOLOGY, 2015, 6
12345678