RP-TLC Determination of the Lipophilicity of Some New Derivatives of 1,2,4-Triazole and Thiosemicarbazide with Potential Antituberculosis Activity

被引：0
作者：
J. Flieger
M. Tatarczak
M. Wujec
M. Pitucha
H. Szumiło
机构：
[1] Medical University of Lublin,Department of Inorganic and Analytical Chemistry
[2] Medical University of Lublin,Department of Organic Chemistry
来源：
JPC – Journal of Planar Chromatography – Modern TLC | 2006年 / 19卷
关键词：
Reversed-phase TLC; Lipophilicity 1,2,4-Triazole derivatives; Thiosemicarbazide derivatives;
D O I：
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学科分类号：
摘要：
The reversed-phase thin layer chromatographic retention behavior of some new derivatives of 1,2,4-triazole and thiosemicarbazide has been determined. Linear relationships were established between the retention (RM) of each solute and the volume fraction of organic modifier (methanol or acetonitrile) in organic-aqueous mobile phases. This enabled determination of chromatographic lipophilic-ity data - RMW values by extrapolation, φ0 by interpolation for each organic modifier, and S denoting the slope of the linear dependences. Moderate correlation was established between chromato-graphic lipophilicity and log PG calculated by use of Chem Plus software. Experimental lipophilicity log PTLC was also determined for each solute by the use of a special calibration plot prepared by use of selected sulfonamide standards for the two mobile phase systems used in this study. The effect of different mobile-phase modifiers on experimentally obtained lipophilicity was studied and compared.
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页码：32 / 41
页数：9
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