Functionalization of 2,3,4,5-Tetrahydro-1,5-benzodiazepin-2(1H)-ones by Electrophilic Aromatic Substitution

被引：0
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作者：
Regina Janciene
Ausra Vektariene
Zita Stumbreviciute
Lidija Kosychova
Kazimieras Konstantinavicius
Benedikta D. Puodziunaite
机构：
[1] Institute of Biochemistry,
[2] LT-2600 Vilnius,undefined
[3] Lithuania,undefined
来源：
Monatshefte für Chemie / Chemical Monthly | 2003年 / 134卷
关键词：
Keywords. 2,3,4,5-Tetrahydro-1,5-benzodiazepin-2(1H)-ones; Electrophilic substitution; Hydrolysis; Semiempirical calculations.;
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摘要：
Highly substituted, novel, 8- and 9-nitro-2,3,4,5-tetrahydro-1,5-benzodiazepin-2(1H)-ones were obtained by direct nitration of the 7-bromo-5-trifluoroacetyl (or formyl)-substituted tetrahydrobenzodiazepinones. Alkaline and acidic hydrolysis of the novel mononitro derivatives was examined. Semiempirical AM1 calculations of aromatic substituents orientation in the nitration products are presented.
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页码：1629 / 1639
页数：10
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