Mast Cells in Renal Cancer: Clinical Morphological Correlations and Prognosis

被引：0

作者：

T. M. Cherdantseva

I. P. Bobrov

A. M. Avdalyan

V. V. Klimachev

A. V. Kazartsev

N. G. Kryuchkova

I. V. Klimachev

M. N. Myadelets

A. V. Lepilov

E. L. Lushnikova

O. P. Molodykh

机构：

[1] Altai State Medical University,

[2] the Ministry of Health of the Russian Federation,undefined

[3] Altai Affiliated Department,undefined

[4] N. N. Blokhin Russian Oncological Center,undefined

[5] the Ministry of Health of the Russian Federation,undefined

[6] Institute of Molecular Pathology and Pathomorphology,undefined

来源：

Bulletin of Experimental Biology and Medicine | 2017年 / 163卷

关键词：

renal cancer; mast cells; peritumorous zone; angiogenesis; 5-year survival;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Morphofunctional activity of mast cells in renal cancer is studied on specimens from the center of the tumor, peritumorous zone (with an obligatory fragment of the pseudocapsule), and from renal tissues maximally distant from the tumor. The counts and areas of tumor cells were maximum in the peritumorous zone in comparison with intact kidney tissue and central zone of the tumor. Analysis of correlations revealed a direct correlation between the tumor cell count in the peritumorous zone and some clinical morphological parameters of the tumor (anaplasia degree, size, presence of invasion and metastases, and angiogenesis). The count of mast cells in the renal peritumorous zone inversely correlated with 5-year survival: 100% cumulative 5-year survival in patients with mast cell count <6.7±1.6 per field of view.

引用

页码：801 / 804

页数：3

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