Alkylating Damage by Dipin of Hematopoietic and Stromal Cells of the Bone Marrow

被引：0
作者：
E. I. Domaratskaya
E. I. Bueverova
O. D. Payushina
V. I. Starostin
机构：
[1] Russian Academy of Sciences,Kol’tsov Institute of Developmental Biology
来源：
Biology Bulletin | 2005年 / 32卷
关键词：
Bone Marrow; Progenitor Cell; Stromal Cell; Dipin; Single Administration;
D O I：
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学科分类号：
摘要：
Effect of alkylating agent dipin was studied on hematopoietic (CFU-S) and stromal (CFU-F) progenitor cells. Single administration of dipin (0.06 mg/g) to adult (CBA × C57Bl/6) F1 hybrid mice induced a long-term (2 years) oscillations in the numbers of day 7 CFU-S and day 11 CFU-S in the bone marrow and spleen. Dipin also damaged the hematopoietic stroma as indicated by decreased numbers of CFU-F which remained low for at least a year. The capacity of stromal cells to form ectopic hematopoietic foci was considerably decreased and also remained low for 10 months. The obtained data suggest high dipin sensitivity of the earliest hematopoietic and stromal cells. The dynamics of CFU-S numbers in the hematopoietic organs supports their functioning on the basis of clonal succession (Kay, 1965).
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页码：216 / 220
页数：4
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