Synthesis and Biological Activity of Nitrilic Derivatives of the Methyl Ester of Maleopimaric Acid

被引：0
作者：
E. V. Tret’yakova
E. V. Salimova
L. V. Parfenova
机构：
[1] Russian Academy of Sciences,Institute of Petrochemistry and Catalysis
来源：
Russian Journal of Bioorganic Chemistry | 2018年 / 44卷
关键词：
diterpenoids; levopimaric acid; maleopimaric acid; methyl ester; cytotoxic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An effective method of a modification of the anhydride ring of the maleopimaric acid methyl ester by means of the cyanoethylation reaction was developed. A primary screening of a cytotoxic activity in vitro demonstrated an ability of the cyanoethyl derivative of the maleopimaric acid methyl ester to induce the death of the PC-3 cells of prostate cancer.
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页码：547 / 552
页数：5
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