Carrier Mechanisms Involved in the Transepithelial Transport of bis(POM)-PMEA and Its Metabolites Across Caco-2 Monolayers

[1] Naesens L.(1996)Antiretroviral activity and pharmacokinetics in mice of oral bis-(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine Antimicrob. Agents Chemother. 40 22-28

[2] Balzarini J.(1997)Anti-human immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-bis-(pivaloyloxymethyl)phosphonyl-methoxyethyl]adenine) in HIV infected patients J. Inf. Dis. 176 406-413

[3] Bischofberger N.(1990)Epithelial Transport of Drugs in Cell Culture. I: A Model for Studying the Passive Diffusion of Drugs over Intestinal Absorptive (Caco-2) Cells J. Pharm. Sci. 79 476-482

[4] De Clercq E.(1990)The use of cultured epithelial and endothelial cells for drug transport and metabolism studies Pharm. Res. 7 435-451

[5] Barditch-Crovo P. A.(1990)Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa Pharm. Res. 7 902-910

[6] Toole J.(1994)Use of Caco-2 Cells as an in vitro intestinal absorption and metabolism model Drug Dev. Ind. Pharm. 20 615-631

[7] Hendrix C. W.(1997)Transport, uptake and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an Pharm. Res. 14 492-496

[8] Cundy K. C.(1998)cell culture system of the intestinal mucosa (Caco-2) Pharm. Res. 15 243-249

[9] Ebeling D.(1993)Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxy-ethyl)adenine [PMEA] in Caco-2 monolayers Pharm. Res. 10 743-749

[10] Jaffe H. S.(1995)Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers Cancer Res. 55 1663-1638

[1] Naesens L.(1996)Antiretroviral activity and pharmacokinetics in mice of oral bis-(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine Antimicrob. Agents Chemother. 40 22-28

[2] Balzarini J.(1997)Anti-human immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-bis-(pivaloyloxymethyl)phosphonyl-methoxyethyl]adenine) in HIV infected patients J. Inf. Dis. 176 406-413

[3] Bischofberger N.(1990)Epithelial Transport of Drugs in Cell Culture. I: A Model for Studying the Passive Diffusion of Drugs over Intestinal Absorptive (Caco-2) Cells J. Pharm. Sci. 79 476-482

[4] De Clercq E.(1990)The use of cultured epithelial and endothelial cells for drug transport and metabolism studies Pharm. Res. 7 435-451

[5] Barditch-Crovo P. A.(1990)Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa Pharm. Res. 7 902-910

[6] Toole J.(1994)Use of Caco-2 Cells as an in vitro intestinal absorption and metabolism model Drug Dev. Ind. Pharm. 20 615-631

[7] Hendrix C. W.(1997)Transport, uptake and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an Pharm. Res. 14 492-496

[8] Cundy K. C.(1998)cell culture system of the intestinal mucosa (Caco-2) Pharm. Res. 15 243-249

[9] Ebeling D.(1993)Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxy-ethyl)adenine [PMEA] in Caco-2 monolayers Pharm. Res. 10 743-749

[10] Jaffe H. S.(1995)Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers Cancer Res. 55 1663-1638