Carrier Mechanisms Involved in the Transepithelial Transport of bis(POM)-PMEA and Its Metabolites Across Caco-2 Monolayers

被引：0
|
作者：
P. Annaert
J. Van Gelder
L. Naesens
E. De Clercq
G. Van den Mooter
R. Kinget
P. Augustijns
机构：
[1] Laboratorium voor Farmacotechnologie en Biofarmacie,
[2] KULeuven,undefined
[3] Campus Gasthuisberg,undefined
[4] O + N,undefined
[5] Rega Institute for Medical Research,undefined
[6] KULeuven,undefined
来源：
Pharmaceutical Research | 1998年 / 15卷
关键词：
bis(POM)-PMEA; Caco-2; carrier mechanisms; P-glycoprotein; multi drug resistance; antiviral; drug transport; drug efflux;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. To investigate the role of carrier mechanisms in: [1] the polarized transport of the bis(pivaloyloxymethyl)- [bis(POM)-] ester prodrug of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] and [2] the directional secretion of its metabolites.
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收藏
页码：1168 / 1173
页数：5
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