Mitogen-activated protein kinases in apoptosis regulation

被引:0
作者
Teiji Wada
Josef M Penninger
机构
[1] IMBA: Institute of Molecular Biotechnology of the Austrian Academy of Sciences,
[2] Dr Bohr-gasse3–5,undefined
来源
Oncogene | 2004年 / 23卷
关键词
stress; programmed cell death; signal transduction; JNK/SAPK; ERK; p38-MAPK;
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摘要
Cells are continuously exposed to a variety of environmental stresses and have to decide ‘to be or not to be’ depending on the types and strength of stress. Among the many signaling pathways that respond to stress, mitogen-activated protein kinase (MAPK) family members are crucial for the maintenance of cells. Three subfamilies of MAPKs have been identified: extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinases (JNKs), and p38-MAPKs. It has been originally shown that ERKs are important for cell survival, whereas JNKs and p38-MAPKs were deemed stress responsive and thus involved in apoptosis. However, the regulation of apoptosis by MAPKs is more complex than initially thought and often controversial. In this review, we discuss MAPKs in apoptosis regulation with attention to mouse genetic models and critically point out the multiple roles of MAPKs.
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页码:2838 / 2849
页数:11
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