Human CD8+ T cell cross-reactivity across influenza A, B and C viruses

被引：0
作者：
Marios Koutsakos
Patricia T. Illing
Thi H. O. Nguyen
Nicole A. Mifsud
Jeremy Chase Crawford
Simone Rizzetto
Auda A. Eltahla
E. Bridie Clemens
Sneha Sant
Brendon Y. Chua
Chinn Yi Wong
E. Kaitlynn Allen
Don Teng
Pradyot Dash
David F. Boyd
Ludivine Grzelak
Weiguang Zeng
Aeron C. Hurt
Ian Barr
Steve Rockman
David C. Jackson
Tom C. Kotsimbos
Allen C. Cheng
Michael Richards
Glen P. Westall
Thomas Loudovaris
Stuart I. Mannering
Michael Elliott
Stuart G. Tangye
Linda M. Wakim
Jamie Rossjohn
Dhanasekaran Vijaykrishna
Fabio Luciani
Paul G. Thomas
Stephanie Gras
Anthony W. Purcell
Katherine Kedzierska
机构：
[1] University of Melbourne,Department of Microbiology and Immunology
[2] at the Peter Doherty Institute for Infection and Immunity,Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute
[3] Monash University,Department of Immunology
[4] St Jude Children’s Research Hospital,School of Medical Sciences and The Kirby Institute
[5] UNSW,Research Center for Zoonosis Control
[6] Hokkaido University,Infection and Immunity Program & Department of Microbiology, Biomedicine Discovery Institute
[7] Monash University,Biology Department, École Normale Supérieure Paris
[8] Université Paris-Saclay,Saclay
[9] World Health Organization (WHO) Collaborating Centre for Reference and Research on Influenza,School of Applied Biomedical Sciences
[10] at The Peter Doherty Institute for Infection and Immunity,Department of Allergy, Immunology and Respiratory Medicine
[11] Federation University,Department of Medicine
[12] Seqirus,School of Public Health and Preventive Medicine
[13] The Alfred Hospital,Infection Prevention and Healthcare Epidemiology Unit
[14] Monash University,Victorian Infectious Diseases Service
[15] Central Clinical School,Lung Transplant Unit
[16] The Alfred Hospital,Immunology and Diabetes Unit
[17] Monash University,Sydney Medical School
[18] Alfred Health,Chris O’Brien Lifehouse Cancer Centre
[19] The Royal Melbourne Hospital,Immunology Division
[20] at the Peter Doherty Institute for Infection and Immunity,St. Vincent’s Clinical School
[21] Alfred Hospital,Australian Research Council Centre of Excellence for Advanced Molecular Imaging
[22] St Vincent’s Institute of Medical Research,undefined
[23] University of Sydney,undefined
[24] Royal Prince Alfred Hospital,undefined
[25] Garvan Institute of Medical Research,undefined
[26] University of New South Wales,undefined
[27] Monash University,undefined
[28] Institute of Infection and Immunity,undefined
[29] Cardiff University School of Medicine,undefined
[30] Heath Park,undefined
来源：
Nature Immunology | 2019年 / 20卷
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摘要：
Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross-protection against IAV strains, however the responses of CD8+ T cells to IBV and ICV are understudied. We investigated the breadth of CD8+ T cell cross-recognition and provide evidence of CD8+ T cell cross-reactivity across IAV, IBV and ICV. We identified immunodominant CD8+ T cell epitopes from IBVs that were protective in mice and found memory CD8+ T cells directed against universal and influenza-virus-type-specific epitopes in the blood and lungs of healthy humans. Lung-derived CD8+ T cells displayed tissue-resident memory phenotypes. Notably, CD38+Ki67+CD8+ effector T cells directed against novel epitopes were readily detected in IAV- or IBV-infected pediatric and adult subjects. Our study introduces a new paradigm whereby CD8+ T cells confer unprecedented cross-reactivity across all influenza viruses, a key finding for the design of universal vaccines.
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页码：613 / 625
页数：12
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