Comparison of a laboratory and a production coating spray gun with respect to scale-up

被引：0
|
作者：
Ronny Mueller
Peter Kleinebudde
机构：
[1] Heinrich-Heine-University,Institute of Pharmaceutics and Biopharmaceutics
来源：
AAPS PharmSciTech | / 8卷
关键词：
Atomization; film coating; spray gun; scale-up; design of experiments;
D O I：
暂无
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学科分类号：
摘要：
A laboratory spray gun and a production spray gun were investigated in a scale-up study. Two Schlick spray guns, which are equipped with a new antibearding cap, were used in this study. The influence of the atomization air pressure, spray gun-to tablet bed distance, polymer solution viscosity, and spray rate were analyzed in a statistical design of experiments. The 2 spray guns were compared with respect to the spray width and height, droplet size, droplet velocity, and spray density. The droplet size, velocity, and spray density were measured with a Phase Doppler Particle Analyzer.
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