Oxidative mechanism of arsenic toxicity and carcinogenesis

被引：27
作者：
Honglian Shi
Xianglin Shi
Ke Jian Liu
机构：
[1] University of New Mexico,College of Pharmacy
[2] National Institute for Occupational Safety and Health,Pathology and Physiology Research
来源：
Molecular and Cellular Biochemistry | 2004年 / 255卷
关键词：
arsenic; free radicals; oxidative stress; signal transduction; carcinogenesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Arsenic is a known toxin and carcinogen that is present in industrial settings and in the environment. The mechanisms of disease initiation and progression are not fully understood. In the last a few years, there has been increasing evidence of the correlation between the generation of reactive oxygen species (ROS), DNA damage, tumor promotion, and arsenic exposure. This article summarizes the current literature on the arsenic mediated generation of ROS and reactive nitrogen species (RNS) in various biological systems. This article also discusses the role of ROS and RNS in arsenic-induced DNA damage and activation of oxidative sensitive gene expression.
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页码：67 / 78
页数：11
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