Nanocarrier Mediated Cytosolic Delivery of Drug, DNA and Proteins

被引：1
作者：
Shailja Tiwari
Madhu Gupta
Suresh P. Vyas
机构：
[1] Dr. Harisingh Gour Vishwavidyalaya,Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences
来源：
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences | 2012年 / 82卷 / Suppl 1期
关键词：
Macromolecular drugs; Cytosol; Endosomal escape; Therapeutic molecules; Nanocarriers; Bioactives;
D O I：
10.1007/s40011-012-0078-1
中图分类号：
学科分类号：
摘要：
Recent researches have focused on the development of a number of macromolecular drugs such as DNA, protein and drugs that are intended to exert their action in cytosol or other intracellular organelle. The major hurdle encountered in their in vivo utilization is endosomal escape of drugs. The advent in research on nanotechnology has offered a number of optional nanocarriers which demonstrate numerous advantages in specialized drug delivery applications. These advantages include stabilization, controlled release and site specific delivery of therapeutic molecules. In addition, the cytosolic delivery to subcellular compartments can also be achieved by inclusion of pH sensitive molecules (lipid, polymer or peptide) in nanocarrier construct to achieve endosomal escape. A number of molecules have been identified that in combination with nanocarriers mediate cytosolic delivery of bioactives.
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页码：127 / 150
页数：23
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