The impact of the CYP2D6 and CYP2C19 genotypes on venlafaxine pharmacokinetics in a Japanese population

被引：0

作者：

T. Fukuda

Y. Nishida

Q. Zhou

I. Yamamoto

S. Kondo

J. Azuma

机构：

[1] Clinical Evaluation of Medicines and Therapeutics Graduate School of Pharmaceutical Sciences,

[2] Osaka University,undefined

[3] 1-6 Yamada-oka Suita Osaka 565-0871,undefined

[4] Japan e-mail: azuma@phs.osaka-u.ac.jp Tel.:+81-6-68798258; Fax:+81-6-68798259,undefined

[5] Osaka Pharmacology Research Clinic,undefined

[6] Suita,undefined

[7] Osaka,undefined

[8] Japan,undefined

来源：

European Journal of Clinical Pharmacology | 2000年 / 56卷

关键词：

Key words CYP2D6; CYP2C19; Polymorphism;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Objective: The cytochrome P450 isozymes CYP2D6 and CYP2C19 exhibit genetic polymorphism in human, including a marked interethnic difference. As the functional status of the isozymes CYP2D6 and CYP2C19 have an impact on the pharmacokinetics of some antidepressants, we investigated whether the disposition of venlafaxine was affected by the CYP2D6 and CYP2C19 genotypes.

引用

页码：175 / 180

页数：5