B cells regulate autoimmunity by provision of IL-10

被引：0
作者：
Simon Fillatreau
Claire H. Sweenie
Mandy J. McGeachy
David Gray
Stephen M. Anderton
机构：
[1] University of Edinburgh,
[2] Institute of Cell,undefined
[3] Animal and Population Biology,undefined
来源：
Nature Immunology | 2002年 / 3卷
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摘要：
To assess the importance of B cell control of T cell differentiation, we analyzed the course of the T helper type 1 (TH1)-driven disease experimental autoimmune encephalomyelitis in mice with an altered B cell compartment. We found that recovery was dependent on the presence of autoantigen-reactive B cells. B cells from recovered mice produced interleukin 10 (IL-10) in response to autoantigen. With a bone marrow chimeric system, we generated mice in which IL-10 deficiency was restricted to B cells but not T cells. In the absence of IL-10 production by B cells, the pro-inflammatory type 1 immune response persisted and mice did not recover. These data show that B cell–derived IL-10 plays a key role in controlling autoimmunity.
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页码：944 / 950
页数：6
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