Upregulation of Wnt5a promotes epithelial-to-mesenchymal transition and metastasis of pancreatic cancer cells

被引:0
作者
Haiji Bo
Shuhui Zhang
Li Gao
Ying Chen
Jing Zhang
Xuejiao Chang
Minghua Zhu
机构
[1] Second Military Medical University,Department of Pathology, Changhai Hospital
[2] Shanghai University of Traditional Chinese Medicine,Department of Pathology, Yueyang Hospital
来源
BMC Cancer | / 13卷
关键词
Pancreatic cancer; Wnt5a; Epithelial-to-mesenchymal transition; Metastasis;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 177 条
[11]  
Xu J(2011)Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition Genes Cells 16 304-27543
[12]  
Murray T(2012)Wnt5a promotes ewing sarcoma cell migration through upregulating CXCR4 expression BMC Cancer 12 480-1187
[13]  
Thun MJ(2012)An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis Mol Cancer Ther 11 298-519
[14]  
Vincent A(2009)Wnt-5a-induced phosphorylation of DARPP-32 inhibits breast cancer cell migration in a CREB-dependent manner J Biol Chem 284 27533-2154
[15]  
Herman J(2007)WNT5A–target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer Carcinogenesis 28 1178-567
[16]  
Schulick R(2002)Frequent up-regulation of WNT5A mRNA in primary gastric cancer Int J Mol Med 9 515-579
[17]  
Hruban RH(2012)Wnt5a is strongly expressed at the leading edge in non-melanoma skin cancer, forming active gradients, while canonical Wnt signalling is repressed PLoS One 7 e31827-17271
[18]  
Goggins M(2005)Wnt-5a has tumor suppressor activity in thyroid carcinoma Oncogene 24 2144-11748
[19]  
Langley RR(2008)Expression of Wnt-5a and its clinicopathological significance in hepatocellular carcinoma Dig Liver Dis 40 560-219
[20]  
Fidler IJ(2013)MicroRNA-374a activates Wnt/beta-catenin signaling to promote breast cancer metastasis J Clin Invest 123 566-2786