Nonviral delivery systems for small interfering RNAs

被引：0
作者：
K. V. Glebova
A. V. Marakhonov
A. V. Baranova
M. Yu. Skoblov
机构：
[1] Russian Academy of Medical Sciences,Research Center for Medical Genetics
[2] George Mason University,School of Systems Biology
来源：
Molecular Biology | 2012年 / 46卷
关键词：
RNA interference; siRNA; siRNA delivery;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
RNA interference is now considered to be the most powerful and promising tool for gene-targeted therapy. Several problems are still to be solved for its successful use in medicine. One of the main issues is efficient siRNA delivery. The review considers various types of nonviral siRNA delivery systems.
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页码：349 / 361
页数：12
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  • [21] Nicolau C.(2009)Controlling HBV replication in vivo by intravenous administration of triggered PEGylated siRNA-nanoparticles Mol. Pharm. 6 706-569
  • [22] Felgner P.L.(2008)A combinatorial library of lipid-like materials for delivery of RNAi therapeutics Nature Biotechnol. 26 561-2943
  • [23] Ringold G.M.(2007)Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system Cancer Res. 67 2938-340
  • [24] Ozpolat B.(2004)The design and exogenous delivery of siRNA for post-transcriptional gene silencing J. Drug Target. 12 315-155
  • [25] Sood A.K.(2006)Delivery strategies for siRNA-mediated gene silencing Curr. Drug Deliv. 3 147-323
  • [26] Lopez-Berestein G.(2003)Toxicogenomics of non-viral vectors for gene therapy: A microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells J. Drug Target. 11 311-462
  • [27] Arnold A.S.(2005)Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA Nature Biotechnol. 23 457-1640
  • [28] Tang Y.L.(2006)Ligand-targeted delivery of therapeutic siRNA Pharm. Res. 23 1631-6918
  • [29] Qian K.(2009)Advances in systemic siRNA delivery Drugs Future. 34 721-4924
  • [30] Shen L.(2005)Therapeutic Cancer Res. 65 6910-120
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