Pleomorphic myxoid liposarcoma in an adolescent with Li–Fraumeni syndrome

被引：0
作者：
Tiffany J. Sinclair
Chad M. Thorson
Elysia Alvarez
Serena Tan
Sheri L. Spunt
Stephanie D. Chao
机构：
[1] Stanford University School of Medicine,Department of Surgery
[2] Stanford University School of Medicine,Division of Pediatric Surgery, Department of Surgery
[3] Stanford University School of Medicine,Division of Pediatric Hematology/Oncology, Department of Pediatrics
[4] Stanford University School of Medicine,Department of Pathology
来源：
Pediatric Surgery International | 2017年 / 33卷
关键词：
Sarcoma; TP53 mutation; Hereditary cancer syndrome; Li–Fraumeni syndrome;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We present the case of a 15-year-old female with a right perineal mass that was found to be pleomorphic myxoid liposarcoma, a recently recognized, rare subtype of liposarcoma. The patient had a strong family history of malignancy and genetic screening revealed a pathogenic TP53 mutation consistent with Li–Fraumeni syndrome.
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页码：631 / 635
页数：4
相关论文
共 158 条
  • [1] Coffin CM(2012)Adipose and myxoid tumors of childhood and adolescence Pediatr Dev Pathol 15 239-254
  • [2] Alaggio R(1983)Liposarcoma occurring in children. An analysis of 17 cases and review of the literature Cancer 52 567-574
  • [3] Shmookler BM(1984)Childhood liposarcoma. Report of a case and review of the literature Cancer 54 579-584
  • [4] Enzinger FM(1993)Liposarcoma in patients younger than or equal to 22 years of age Cancer 72 3114-3119
  • [5] Castleberry RP(1999)Childhood liposarcoma: a single-institutional twenty-year experience Pediatr Hematol Oncol 16 415-421
  • [6] Kelly DR(2011)Liposarcoma in children and young adults: a multi-institutional experience Pediatr Blood Cancer 57 1142-1146
  • [7] Wilson ER(2009)Liposarcomas in young patients: a study of 82 cases occurring in patients younger than 22 years of age Am J Surg Pathol 33 645-658
  • [8] Cain WS(1959)Lipoblastic tumors of children Cancer 12 912-925
  • [9] Salter MR(2014)Array-based comparative genomic hybridization analysis of a pleomorphic myxoid liposarcoma J Clin Pathol 67 834-835
  • [10] La Quaglia MP(2016)Comprehensive genetic analysis of a paediatric pleomorphic myxoid liposarcoma reveals near-haploidization and loss of the RB1 gene Histopathology 69 141-147
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