The influence of sodium on pathophysiology of multiple sclerosis

被引：0
作者：
Jacek Zostawa
Jowita Adamczyk
Paweł Sowa
Monika Adamczyk-Sowa
机构：
[1] Medical University of Silesia,Department of Neurology in Zabrze
[2] Medical University of Silesia,Department of Otorhinolaryngology and Oncological Laryngology
来源：
Neurological Sciences | 2017年 / 38卷
关键词：
Sodium chloride intake; Multiple sclerosis; Environmental factors in MS; VGSCs;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune disease of the central nervous system, and is an important cause of disability in young adults. In genetically susceptible individuals, several environmental factors may play a partial role in the pathogenesis of MS. Some studies suggests that high-salt diet (>5 g/day) may contribute to the MS and other autoimmune disease development through the induction of pathogenic Th17 cells and pro-inflammatory cytokines in both humans and mice. However, the precise mechanisms of pro-inflammatory effect of sodium chloride intake are not yet explained. The purpose of this review was to discuss the present state of knowledge on the potential role of environmental and dietary factors, particularly sodium chloride on the development and course of MS.
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页码：389 / 398
页数：9
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