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Univ Manitoba, Inst Cardiovasc Sci,Dept Physiol & Pathophysiol, St Boniface Hosp,Albrechtsen Res Ctr, Rady Coll Med,Max Rady Fac Hlth Sci, Winnipeg, MB R2H 2H6, Canada Univ Manitoba, Inst Cardiovasc Sci,Dept Physiol & Pathophysiol, St Boniface Hosp,Albrechtsen Res Ctr, Rady Coll Med,Max Rady Fac Hlth Sci, Winnipeg, MB R2H 2H6, Canada