Combined effect of pancreatic lipid content and gene variants (TCF7L2, WFS1 and 11BHSD1) on B-cell function in Middle Aged Women in a Post Hoc Analysis

被引:0
作者
Ákos Nádasdi
Viktor Gál
Tamás Masszi
Attila Patócs
Peter Igaz
Anikó Somogyi
Gábor Firneisz
机构
[1] Semmelweis University,Department of Internal Medicine and Haematology, Faculty of Medicine
[2] Eötvös Loránd Research Network,Brain Imaging Centre, Research Centre for Natural Sciences
[3] MTA-SE Hereditary Tumors Research Group,Department of Laboratory Medicine, Faculty of Medicine
[4] Eötvös Loránd Research Network,Department of Endocrinology, Faculty of Medicine
[5] Semmelweis University,Department of Internal Medicine and Oncology, Faculty of Medicine
[6] MTA-SE Molecular Medicine Research Group,undefined
[7] Eötvös Loránd Research Network,undefined
[8] Semmelweis University,undefined
[9] Semmelweis University,undefined
来源
Diabetology & Metabolic Syndrome | / 14卷
关键词
Pancreatic fat ; Liver fat ; HbA1c ;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 267 条
  • [21] Woodcock SA(2007)Genetics of type 2 diabetes—pitfalls and possibilities J Clin Invest 117 2155-82
  • [22] Pucci A(2014)Mechanisms by which common variants in the Hum Mol Genet 23 6419-13
  • [23] Aribisala B(2017) gene increase risk of type 2 diabetes Diabetes Care 40 1082-8
  • [24] Firneisz G(2018)TCF7L2 is a master regulator of insulin production and processing Diabetologia 61 2189-51
  • [25] Gaborit B(2009)The rs7903146 variant in the Diabetologia 52 1075-22
  • [26] Abdesselam I(2018) gene increases the risk of prediabetes/type 2 diabetes in obese adolescents by impairing β-cell function and hepatic insulin sensitivity Nat Genet 50 1505-77
  • [27] Kober F(2016)Activation of GLP-1 receptor signalling alleviates cellular stresses and improves beta cell function in a mouse model of Wolfram syndrome Clin Endocrinol 85 180-9
  • [28] Jacquier A(2016)A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion J Clin Endocrinol Metab 101 4743-2
  • [29] Ronsin O(2017)Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps PLoS ONE 12 e0169781-7
  • [30] Emungania O(2020)Polymorphisms of the GR and HSD11B1 genes influence body mass index and weight gain during hormone replacement treatment in patients with Addison’s disease Diabetologia 63 419-6