Rat serum electrolytes, lipid profile and cardiovascular activity on Nauclea latifolia leaf extract administration

被引：20
作者：
Akpanabiatu M.I. [1 ]
Umoh I.B. [1 ]
Udosen E.O. [1 ]
Udoh A.E. [2 ]
Edet E.E. [1 ]
机构：
[1] Department of Biochemistry, University of Calabar, Calabar
[2] Department of Chemical Pathology, University of Calabar, Calabar
来源：
Indian Journal of Clinical Biochemistry | 2005年 / 20卷 / 2期
关键词：
Cardiovascular activity; Electrolytes; Lipid profile; Nauclea latifolia;
D O I：
10.1007/BF02867397
中图分类号：
学科分类号：
摘要：
Aqueous extract of the leaf and root of Nauclea latifolia Sm. (Rubiaceae) is used in Nigerian folk medicine for the treatment of hypertension. This work is carried out to investigate the effect of Nauclea latifolia leaf extract on lipid profile and cardiovascular activity of rats. Normal and 10% coconut oil fed rats were treated with the water-soluble fraction of the ethanol extract of Nauclea latifolia leaf for 2 weeks. Forty-eight mature male albino rats of the Wistar strain were divided into two experiments of four groups, each group having 6 animals. Experiment I animals were treated with the water-soluble fraction of the ethanol extract whilst experiment II animals were fed 10% coconut oil meal before treatment with the water-soluble fraction of the ethanol extract. A single oral dose of Nauclea latifolia was 170, 340 and 510 mg/kg body wt/day of the extracts respectively for 2 wks. There was no significant change in the lipid profile of the experimental animals as compared with the controls. There was about 40% relaxation on contracted thoracic aorta that was pre-contracted with 2 μM phenylephrine. The viability of the tissue was tested against 10 μM of acetylcholine. There was no significant (P > 0.05) change in Na+ concentration in the serum. However, the K+ concentration in the serum of the experimental animals showed a significant increase. The study shows that ethanol extract of Nauclea latifolia has vasodilator action on the aorta and that lipid profiles of experimental rats were not affected. Furthermore, the increase in the K+ may be contributing to the vasodilator effect of Nauclea latifolia.
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页码：29 / 34
页数：5
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