An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

被引：0
作者：
Birgit Knoechel
Justine E Roderick
Kaylyn E Williamson
Jiang Zhu
Jens G Lohr
Matthew J Cotton
Shawn M Gillespie
Daniel Fernandez
Manching Ku
Hongfang Wang
Federica Piccioni
Serena J Silver
Mohit Jain
Daniel Pearson
Michael J Kluk
Christopher J Ott
Leonard D Shultz
Michael A Brehm
Dale L Greiner
Alejandro Gutierrez
Kimberly Stegmaier
Andrew L Kung
David E Root
James E Bradner
Jon C Aster
Michelle A Kelliher
Bradley E Bernstein
机构：
[1] Massachusetts General Hospital and Harvard Medical School,Department of Pathology
[2] Broad Institute of MIT and Harvard,Department of Pediatric Oncology
[3] Dana-Farber Cancer Institute,Division of Hematology/Oncology
[4] Boston Children's Hospital and Harvard Medical School,Department of Cancer Biology
[5] University of Massachusetts Medical School,Department of Medical Oncology
[6] Center for Cancer Research,Department of Pathology
[7] Massachusetts General Hospital,Department of Molecular Biology
[8] Howard Hughes Medical Institute,undefined
[9] Dana-Farber Cancer Institute,undefined
[10] Biostatistics Graduate Program,undefined
[11] Harvard University,undefined
[12] Brigham and Women's Hospital and Harvard Medical School,undefined
[13] Center for Human Genetic Research,undefined
[14] Massachusetts General Hospital,undefined
[15] Massachusetts General Hospital,undefined
[16] Biological and Biomedical Sciences Graduate Program,undefined
[17] Harvard Medical School,undefined
[18] Jackson Laboratory,undefined
[19] Program in Molecular Medicine,undefined
[20] University of Massachusetts Medical School,undefined
来源：
Nature Genetics | 2014年 / 46卷
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学科分类号：
摘要：
Michelle Kelliher, Bradley Bernstein and colleagues identify T cell acute lymphoblastic leukemia cells that are resistant to γ-secretase inhibitor treatment and characterize the epigenetic mechanism of resistance.
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页码：364 / 370
页数：6
相关论文
共 74 条
[1]  
Weng AP(2004)Activating mutations of Science 306 269-271
[2]  
Ellisen LW(1991) in human T cell acute lymphoblastic leukemia Cell 66 649-661
[3]  
Pui CH(2006), the human homolog of the N. Engl. J. Med. 354 166-178
[4]  
Evans WE(2009) gene, is broken by chromosomal translocations in T lymphoblastic neoplasms Cancer Res. 69 3060-3068
[5]  
Rao SS(2009)Treatment of acute lymphoblastic leukemia Clin. Lymphoma Myeloma 9 S205-S210
[6]  
Palomero T(2012)Inhibition of NOTCH signaling by γ secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells Nat. Rev. Genet. 13 654-666
[7]  
Ferrando A(2006)Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia Genes Dev. 20 2096-2109
[8]  
Guruharsha KG(2006)The Notch signalling system: recent insights into the complexity of a conserved pathway Proc. Natl. Acad. Sci. USA 103 18261-18266
[9]  
Kankel MW(2006)c- Mol. Cell. Biol. 26 8022-8031
[10]  
Artavanis-Tsakonas S(2009) is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma Blood 114 647-650
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