Machine-learning and combined analysis of single-cell and bulk-RNA sequencing identified a DC gene signature to predict prognosis and immunotherapy response for patients with lung adenocarcinoma

被引:0
作者
Liangyu Zhang
Maohao Guan
Xun Zhang
Fengqiang Yu
Fancai Lai
机构
[1] Fujian Medical University,Department of Thoracic Surgery, The First Affiliated Hospital
[2] National Regional Medical Center,Department of Thoracic Surgery
[3] Binhai Campus of the First Affiliated Hospital,undefined
[4] Fujian Medical University,undefined
来源
Journal of Cancer Research and Clinical Oncology | 2023年 / 149卷
关键词
Single-cell; Dendritic cell (DC); Machine-learning; Prognosis; Immunotherapy;
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页码:13553 / 13574
页数:21
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[11]  
Vacchelli E(2020)Expression of the topoisomerase II alpha (Top2a) gene in lung adenocarcinoma cells and the association with patient outcomes Med Sci Monit 18 e542-1656
[12]  
Kroemer G(2015)N-Myc downstream regulated gene 2 overexpression reduces matrix metalloproteinase-2 and -9 activities and cell invasion of A549 lung cancer cell line in vitro Iran J Basic Med Sci 15 1648-3399
[13]  
Brahmer JR(2022)Complement-Ary immunity to lung cancer Sci Signal 208 7-4566
[14]  
Tykodi SS(2011)Host type I Ifn signals are required for antitumor Cd8+ T cell responses through Cd8{Alpha}+ dendritic cells J Exp Med 145 3391-44
[15]  
Chow LQ(2022)Nampt: a critical driver and therapeutic target for cancer Int J Biochem Cell Biol 17 4557-1120
[16]  
Hwu WJ(2016)Predictive biomarkers for checkpoint inhibitor-based immunotherapy Lancet Oncol 11 35-1558
[17]  
Topalian SL(2020)Loss of Susd2 expression correlates with poor prognosis in patients with surgically resected lung adenocarcinoma J Cancer 14 1107-711
[18]  
Hwu P(2013)Gsva: gene set variation analysis for microarray and Rna-Seq Data BMC Bioinform 25 1550-2508
[19]  
Braud VM(2021)Clec10a is a prognostic biomarker and correlated with clinical pathologic features and immune infiltrates in lung adenocarcinoma J Cell Mol Med 79 1088-156
[20]  
Biton J(2019)The tumor microenvironment innately modulates cancer progression Cancer Res 165 705-3895