Serum levels of brain-derived neurotrophic factor in Sydenham’s chorea

被引：0
作者：
Antônio Lúcio Teixeira
Thales Lage Bretas
Arthur Kummer
Lívia Cunha Melo
Amanda Baraldi
Estefânia Harsányi
Francisco Cardoso
Elizabeth Ribeiro da Silva Camargos
机构：
[1] Federal University of Minas Gerais,Neurology Group, Department of Internal Medicine, School of Medicine
[2] Federal University of Minas Gerais,Neuroimmunology Group, Laboratory of Immunopharmacology, Institute of Biological Sciences
[3] Federal University of Minas Gerais,Laboratory of Neurobiology, Institute of Biological Sciences
[4] Faculdade de Medicina,Departamento de Clínica Médica
[5] UFMG,undefined
来源：
Neurological Sciences | 2010年 / 31卷
关键词：
BDNF; Sydenham’s chorea; Rheumatic fever;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Sydenham’s chorea (SC) is the neurologic manifestation of rheumatic fever. In addition to involuntary movements, SC patients show behavioral changes, such as hyperactivity, obsessions, and compulsions. Brain-derived neurotrophic factor (BDNF) is related to neuronal development and differentiation. Since BDNF serum levels are altered in a series of neuropsychiatric disorders, such as schizophrenia and Huntington’s disease, we investigated the serum levels of BDNF in SC patients. Eighteen patients with acute SC, 4 with persistent SC and 27 control subjects were included in this study. BDNF was determined by ELISA. There was no significant difference between BDNF serum levels of control and acute SC groups (P = 0.12). Persistent SC patients presented decreased BDNF levels when compared to both control and acute SC groups (P < 0.001). Our results suggest that the persistence of symptoms in SC may be related to structural changes in the central nervous system as expressed by altered BDNF levels.
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页码：399 / 401
页数：2
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