Resonance assignments of the microtubule-binding domain of the C. elegans spindle and kinetochore-associated protein 1

被引：0

作者：

Andras Boeszoermenyi

Jens C. Schmidt

Iain M. Cheeseman

Monika Oberer

Gerhard Wagner

Haribabu Arthanari

机构：

[1] Harvard Medical School,Department of Biological Chemistry and Molecular Pharmacology

[2] University of Graz,Institute of Molecular Biosciences

[3] MIT,Whitehead Institute for Biomedical Research, and Department of Biology

来源：

Biomolecular NMR Assignments | 2014年 / 8卷

关键词：

Ska complex; Kinetochore; Mitosis; Microtubule; NMR resonance assignments;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

During mitosis, kinetochores coordinate the attachment of centromeric DNA to the dynamic plus ends of microtubules, which is hypothesized to pull sister chromatids toward opposing poles of the mitotic spindle. The outer kinetochore Ndc80 complex acts synergistically with the Ska (spindle and kinetochore-associated) complex to harness the energy of depolymerizing microtubules and power chromosome movement. The Ska complex is a hexamer consisting of two copies of the proteins Ska1, Ska2 and Ska3, respectively. The C-terminal domain of the spindle and kinetochore-associated protein 1 (Ska1) is the microtubule-binding domain of the Ska complex. We solved the solution structure of the C. elegans microtubule-binding domain (MTBD) of the protein Ska1 using NMR spectroscopy. Here, we report the resonance assignments of the MTBD of C. elegans Ska1.

引用

页码：275 / 278

页数：3

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