Resonance assignments of the microtubule-binding domain of the C. elegans spindle and kinetochore-associated protein 1

被引：0

作者：

Andras Boeszoermenyi

Jens C. Schmidt

Iain M. Cheeseman

Monika Oberer

Gerhard Wagner

Haribabu Arthanari

机构：

[1] Harvard Medical School,Department of Biological Chemistry and Molecular Pharmacology

[2] University of Graz,Institute of Molecular Biosciences

[3] MIT,Whitehead Institute for Biomedical Research, and Department of Biology

来源：

Biomolecular NMR Assignments | 2014年 / 8卷

关键词：

Ska complex; Kinetochore; Mitosis; Microtubule; NMR resonance assignments;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

During mitosis, kinetochores coordinate the attachment of centromeric DNA to the dynamic plus ends of microtubules, which is hypothesized to pull sister chromatids toward opposing poles of the mitotic spindle. The outer kinetochore Ndc80 complex acts synergistically with the Ska (spindle and kinetochore-associated) complex to harness the energy of depolymerizing microtubules and power chromosome movement. The Ska complex is a hexamer consisting of two copies of the proteins Ska1, Ska2 and Ska3, respectively. The C-terminal domain of the spindle and kinetochore-associated protein 1 (Ska1) is the microtubule-binding domain of the Ska complex. We solved the solution structure of the C. elegans microtubule-binding domain (MTBD) of the protein Ska1 using NMR spectroscopy. Here, we report the resonance assignments of the MTBD of C. elegans Ska1.

引用

页码：275 / 278

页数：3

共 50 条

[31] High expression of spindle and kinetochore-associated protein 1 predicts early recurrence and progression of non-muscle invasive bladder cancer
Jiang, Sixiong
Tian, Feng
Wang, Qi
Cheng, Wen
Wang, Longxin
Wang, Ying
Sun, Weibing
CANCER BIOMARKERS, 2018, 22 (03) : 543 - 549
[32] Phosphorylated tau and microtubule-associated protein 2 induce neuronal toxicity in C. elegans
Xie, C.
Miyasaka, T.
Yoshimura, S.
Yoshina, S.
Kage-Nakadai, E.
Mitani, S.
Ihara, Y.
JOURNAL OF NEUROCHEMISTRY, 2012, 123 : 99 - 100
[33] Structural and functional analyses of the C. elegans Spindle-Defective Protein 2 ASH domain.
Murph, M.
Singh, S. M.
Schvarzstein, M.
MOLECULAR BIOLOGY OF THE CELL, 2017, 28
[34] Tau phosphorylation in microtubule-binding domain by protein kinase MARK/par-1 regulates neurite formation
Biernat, J
Wu, YZ
Timm, T
Khlistounova, I
Zheng-Fischhofer, QY
Mandelkow, E
Mandelkow, EM
NEUROBIOLOGY OF AGING, 2002, 23 (01) : S268 - S269
[35] The chromokinesin KLP-19 regulates the microtubule overlap in the central spindle of the C. elegans embryo during mitosis, independently of the microtubule bundling protein SPD-1
Redemann, S.
Magaj, M.
Zimyanin, V.
MOLECULAR BIOLOGY OF THE CELL, 2023, 34 (02) : 126 - 126
[36] 1H, 13C and 15N resonance assignments of the kinetochore localisation domain of BUBR1, a central component of the spindle assembly checkpoint
Simpson, Peter J.
Cota, Ernesto
Bolanos-Garcia, Victor M.
BIOMOLECULAR NMR ASSIGNMENTS, 2012, 6 (01) : 115 - 118
[37] 1H, 13C and 15N resonance assignments of the kinetochore localisation domain of BUBR1, a central component of the spindle assembly checkpoint
Peter J. Simpson
Ernesto Cota
Victor M. Bolanos-Garcia
Biomolecular NMR Assignments, 2012, 6 : 115 - 118
[38] Backbone and side-chain 1H, 15N and 13C resonance assignments of the microtubule-binding domain of yeast cytoplasmic dynein in the high and low-affinity states
Takarada, Osamu
Nishida, Noritaka
Kikkawa, Masahide
Shimada, Ichio
BIOMOLECULAR NMR ASSIGNMENTS, 2014, 8 (02) : 379 - 382
[39] LET-99, a novel DEP domain protein required for spindle orientation in early C. elegans embryos
Tsou, BM
Hayashi, A
Rose, LS
MOLECULAR BIOLOGY OF THE CELL, 2001, 12 : 111A - 111A
[40] Backbone and side-chain 1H, 15N and 13C resonance assignments of the microtubule-binding domain of yeast cytoplasmic dynein in the high and low-affinity states
Osamu Takarada
Noritaka Nishida
Masahide Kikkawa
Ichio Shimada
Biomolecular NMR Assignments, 2014, 8 : 379 - 382

← 1 2 3 4 5 →