Neuroprotective Aurones from Sophora japonica

被引：0
作者：
Qinge Ma
Rongrui Wei
Zhipei Sang
机构：
[1] Jiangxi University of Traditional Chinese Medicine,Key Laboratory of Modern Preparation of TCM of Ministry of Education, Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine
[2] Nanyang Normal University,College of Chemistry and Pharmaceutical Engineering
来源：
Chemistry of Natural Compounds | 2019年 / 55卷
关键词：
L.; aurone; neuroprotective;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new aurone, named (Z)-4,5-methylenedioxy-6-hydroxybenzene-2[(2′,3′,4′-trimethoxy)-2-methyl-2(4-methyl-3-penten-1-yl)-2H-1-benzopyran-5-yl)methylene]-3-benzofuranon (1), and nine known aurones (2–10) were isolated from Sophora japonica L. for the first time. Compounds 1–10 were evaluated for their neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells. Compounds 1, 3, 8, and 10 exhibited significant neuroprotective activities with IC50 values in the range of 2.89–6.02 μM.
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页码：265 / 268
页数：3
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