DNA mismatch repair in trinucleotide repeat instability

被引：0
|
作者：
Jinzhen Guo
Luping Chen
Guo-Min Li
机构：
[1] University of Texas Southwestern Medical Center,Department of Radiation Oncology
[2] University of Southern California Keck School of Medicine,Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center
来源：
Science China Life Sciences | 2017年 / 60卷
关键词：
DNA mismatch repair; trinucleotide repeat instability; neurodegenerative diseases; MutSβ;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Trinucleotide repeat expansions cause over 30 severe neuromuscular and neurodegenerative disorders, including Huntington’s disease, myotonic dystrophy type 1, and fragile X syndrome. Although previous studies have substantially advanced the understanding of the disease biology, many key features remain unknown. DNA mismatch repair (MMR) plays a critical role in genome maintenance by removing DNA mismatches generated during DNA replication. However, MMR components, particularly mismatch recognition protein MutSβ and its interacting factors MutLα and MutLγ, have been implicated in trinucleotide repeat instability. In this review, we will discuss the roles of these key MMR proteins in promoting trinucleotide repeat instability.
引用
收藏
页码：1087 / 1092
页数：5
相关论文
共 50 条
  • [1] DNA mismatch repair in trinucleotide repeat instability
    Jinzhen Guo
    Luping Chen
    GuoMin Li
    Science China(Life Sciences), 2017, 60 (10) : 1087 - 1092
  • [2] DNA mismatch repair in trinucleotide repeat instability
    Jinzhen Guo
    Luping Chen
    Guo-Min Li
    Science China(Life Sciences) , 2017, (10) : 1087 - 1092
  • [3] DNA mismatch repair in trinucleotide repeat instability
    Guo, Jinzhen
    Chen, Luping
    Li, Guo-Min
    SCIENCE CHINA-LIFE SCIENCES, 2017, 60 (10) : 1087 - 1092
  • [4] DNA repair and trinucleotide repeat instability
    Lahue, RS
    Slater, DL
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2003, 8 : S653 - S665
  • [5] DNA tandem repeat instability in the Escherichia coli chromosome is stimulated by mismatch repair at an adjacent CAG•CTG trinucleotide repeat
    Blackwood, John K.
    Okely, Ewa A.
    Zahra, Rabaab
    Eykelenboom, John K.
    Leach, David R. F.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (52) : 22582 - 22586
  • [6] Trinucleotide repeat instability via DNA base excision repair
    Lai, Yanhao
    Beaver, Jill M.
    Laverde, Eduardo
    Liu, Yuan
    DNA REPAIR, 2020, 93
  • [7] Slipped strand DNA (S-DNA and SI-DNA), trinucleotide repeat instability and mismatch repair: A short review
    Pearson, CE
    Sinden, RR
    STRUCTURE, MOTION, INTERACTION AND EXPRESSION OF BIOLOGICAL MACROMOLECULES, VOL 2, 1998, : 191 - 207
  • [8] Tissue specificity in DNA repair: lessons from trinucleotide repeat instability
    Dion, Vincent
    TRENDS IN GENETICS, 2014, 30 (06) : 220 - 229
  • [9] DNA repair in trinucleotide repeat ataxias
    Yau, Wai Yan
    O'Connor, Emer
    Sullivan, Roisin
    Akijian, Layan
    Wood, Nicholas W.
    FEBS JOURNAL, 2018, 285 (19) : 3669 - 3682
  • [10] The Startling Role of Mismatch Repair in Trinucleotide Repeat Expansions
    Richard, Guy-Franck
    CELLS, 2021, 10 (05)
12345