Development, validity and responsiveness of the clinical COPD questionnaire

被引：545
作者：
Thys van der Molen
Brigitte WM Willemse
Siebrig Schokker
Nick HT ten Hacken
Dirkje S Postma
Elizabeth F Juniper
机构：
[1] Department of General Practice, University of Groningen, Groningen
[2] Department of Pathology, University Hospital Groningen, Groningen
[3] Department of Pulmonary Diseases, University Hospital Groningen, Groningen
[4] Dept. Clin. Epidemiology/Biostatist., McMaster Univ. of Health Sciences, Hamilton, Ont.
[5] Dept. of General Pract./Primary Care, University of Aberdeen, Aberdeen
来源：
Health and Quality of Life Outcomes | / 1卷 / 1期
关键词：
Chronic Obstructive Pulmonary Disease; Smoking Cessation; Severe Chronic Obstructive Pulmonary Disease; Symptom Domain; Chronic Symptom;
D O I：
10.1186/1477-7525-1-13
中图分类号：
学科分类号：
摘要：
Background: The new Global Obstructive Lung Disease (GOLD) guidelines advice to focus treatment in Chronic Obstructive Pulmonary Disease (COPD) on improvement of functional state, prevention of disease progression and minimization of symptoms. So far no validated questionnaires are available to measure symptom and functional state in daily clinical practice. The aim of this study was to develop and validate the Clinical COPD Questionnaire (CCQ). Methods: Qualitative research with patients and clinicians was performed to generate possible items to evaluate clinical COPD control. Thereafter, an item reduction questionnaire was sent to 77 international experts. Sixty-seven experts responded and the 10 most important items, divided into 3 domains (symptoms, functional and mental state) were included in the CCQ (scale: 0 = best, 6 = worst). Results: Cross-sectional data were collected from 119 subjects (57 COPD, GOLD stage I-III; 18 GOLD stage 0 and 44 (ex)smokers). Cronbach's α was high (0.91). The CCQ scores in patients (GOLD 0-III) were significantly higher than in healthy (ex)smokers. Furthermore, significant correlations were found between the CCQ total score and domains of the SF-36 (ρ = 0.48 to ρ= 0.69) and the SGRQ (ρ = 0.67 to ρ = 0.72). In patients with COPD, the correlation between the CCQ and FEV1%pred was ρ =-0.49. Test-retest reliability was determined in 20 subjects in a 2-week interval (Intra Class Coefficient = 0.94). Thirty-six smokers with and without COPD showed significant improvement in the CCQ after 2 months smoking cessation, indicating the responsiveness of the CCQ. Conclusion: The CCQ is a self-administered questionnaire specially developed to measure clinical control in patients with COPD. Data support the validity, reliability and responsiveness of this short and easy to administer questionnaire. © 2003 van der Molen et al; licensee BioMed Central Ltd.
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页数：10
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