Severe respiratory syncytial virus pulmonary infection in a patient treated with fludarabine for chronic lymphocytic leukemia

被引：0

作者：

P. Eftekhari

K. Lassoued

E. Oksenhendler

C. Scieux

J.-P. Clauvel

机构：

[1] Service d'Immuno-Hématologie,

[2] Hôpital Saint-Louis,undefined

[3] 1,undefined

[4] avenue Claude Vellefaux,undefined

[5] F-75475 Paris cedex 10,undefined

[6] France (Tel.: 33-1-42-49-96-90; Fax: 33-1-42-49-94-72),undefined

[7] Laboratoire de Virologie-Bactériologie,undefined

[8] Hôpital Saint-Louis,undefined

[9] Paris,undefined

[10] France,undefined

来源：

Annals of Hematology | 1998年 / 76卷

关键词：

Key words Respiratory syncytial virus; Fludarabine; Chronic lymphocytic leukemia;

D O I：

暂无

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学科分类号：

摘要：

Fludarabine phosphate is currently proposed for the treatment of refractory chronic lymphocytic leukemia (CLL). CD4 T-lymphocyte depletion, myelosuppression, and subsequent severe infections are the major side effects of fludarabine phosphate therapy. We report here on a heretofore undescribed respiratory syncytial virus (RSV) infection in a patient with a long-standing history of refractory CLL that was treated with fludarabine phosphate. The patient developed a severe infection of the upper and lower respiratory tract with bilateral pulmonary infiltrates and severe hypoxemia. RSV was the only infectious agent that could be isolated, and treatment with aerosolized ribavirin lead to prompt improvement of all symptoms.

引用

页码：225 / 226

页数：1