Focal therapy for prostate cancer: Revolution or evolution?

被引：17

作者：

Turpen R. ^{[1
]}

Rosser C.J. ^{[1
]}

机构：

[1] Department of Urology, University of Florida, Gainesville, FL

来源：

BMC Urology | / 9卷 / 1期

关键词：

Prostate Cancer; Localize Prostate Cancer; Focal Therapy; Magnetic Resonance Spectroscopic Imaging; TRUS Biopsy;

D O I：

10.1186/1471-2490-9-2

中图分类号：

学科分类号：

摘要：

The face of prostate cancer has been dramatically changed since the late 1980s when PSA was introduced as a clinical screening tool. More men are diagnosed with small foci of cancers instead of the advanced disease evident prior to PSA screening. Treatment options for these smaller tumors consist of expectant management, radiation therapy (brachytherapy and external beam radiotherapy) and surgery (cryosurgical ablation and radical prostatectomy). In the highly select patient, cancer specific survival employing any of these treatment options is excellent, however morbidity from these interventions are significant. Thus, the idea of treating only the cancer within the prostate and sparing the non-cancerous tissue in the prostate is quite appealing, yet controversial. Moving forward if we are to embrace the focal treatment of prostate cancer we must: be able to accurately identify index lesions within the prostate, image cancers within the prostate and methodically study the litany of focal therapeutic options available.

引用

共 33 条

[1]

Bostwick D.G., Waters D.J., Farley E.R., Meiers I., Rukstalis D., Cavanaugh W.A., Ragde H., Dineen M.K., Bahn D., Scionti S., Babian R., Ellis D.S., Rewcastle J.C., Burke H.B., Andriole G.L., Onik G., Barqawi A.E., Maksem J., Barzell W.E., Group consensus reports from the Consensus Conference on Focal Treatment of Prostatic Carcinoma, Celebration, Florida, February 24, 2006, Urology, 70, 6 SUPPL., pp. 42-4, (2007)

[2]

Marberger M., Carroll P.R., Zelefsky M.J., Hricak H., Scardino P.T., Abenhaim L.L., New Treatments for Localized Prostate Cancer, Urology, 72, pp. 36-43, (2008)

[3]

Onik G., Vaughan D., Lotenfoe R., Dineen M., Brady J., The "male lumpectomy": Focal therapy for prostate cancer using cryoablation results in 48 patients with at least 2-year follow-up, Urol Oncol, 26, 5, pp. 500-5, (2008)

[4]

Fisher B., Anderson S., Bryant J., Margolese R.G., Deutsch M., Fisher E.R., Jeong J.-H., Wolmark N., Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer, New England Journal of Medicine, 347, 16, pp. 1233-1241, (2002)

[5]

Veronesi U., Cascinelli N., Mariani L., Greco M., Saccozzi R., Luini A., Aguilar M., Marubini E., Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer, New England Journal of Medicine, 347, 16, pp. 1227-1232, (2002)

[6]

Meiers I., Waters D.J., Bostwick D.G., Preoperative Prediction of Multifocal Prostate Cancer and Application of Focal Therapy: Review 2007, Urology, 70, (2007)

[7]

Mouraviev V., Mayes J.M., Madden J.F., Sun L., Polascik T.J., Analysis of laterality and percentage of tumor involvement in 1386 prostatectomized specimens for selection of unilateral focal cryotherapy, Technology in Cancer Research and Treatment, 6, 2, pp. 91-95, (2007)

[8]

Barzell W.E., Melamed M., Appropriate patient selection in the focal treatment of prostate cancer: The role of transperineal 3-dimensional pathologic mapping of the prostate a 4-year experience, Urology, 70, 6 SUPPL., pp. 27-35, (2007)

[9]

Onik G.B., Transperineal 3D mapping biopsy of the prostate: An essential tool in selecting patients for focal prostate cancer therapy, Urol Oncol, 26, 5, pp. 506-10, (2008)

[10]

Andriole G.L., Bullock T.L., Belani J.S., Traxel E., Yan Y., Bostwick D.G., Humphrey P.A., Is there a better way to biopsy the prostate? Prospects for a novel transrectal systematic biopsy approach, Urology, 70, 6 SUPPL., pp. 22-6, (2007)

← 1 2 3 4 →