Formulation of Polyherbal Patches Based on Polyvinyl Alcohol and Hydroxypropylmethyl Cellulose: Characterization and In Vitro Evaluation

被引:0
|
作者
Jirapornchai Suksaeree
Noramon Nawathong
Rinrada Anakkawee
Wiwat Pichayakorn
机构
[1] Rangsit University,Department of Pharmaceutical Chemistry, Faculty of Pharmacy
[2] Rangsit University,The Herbal Medicinal Products Research and Development Center (Cooperation between Rangsit University, Harbin Institute of Technology, and Heilongjiang University of Chinese Medicine), Faculty of Pharmacy
[3] Prince of Songkla University,Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences
来源
AAPS PharmSciTech | 2017年 / 18卷
关键词
(; )-4-(3′,4′-dimethoxyphenyl)but-3-en-l-ol; Luk-Pra-Kob; matrix patches; polyherbal patches; Thai herbal compress ball;
D O I
暂无
中图分类号
学科分类号
摘要
The purpose of this research was to prepare and characterize polyherbal patches made from polyvinyl alcohol (PVA) and hydroxypropylmethyl cellulose (HPMC) with glycerine as a plasticizer. Polyherbal extracts were Luk-Pra-Kob recipes extracted with 95% ethanol. They were prepared by mixing the polymer solutions and glycerine in a beaker; subsequently, the polyherbal extracts were homogeneously mixed. Then, they were transferred into a Petri dish and dried in a hot-air oven at 70 ± 2°C for 5 h. The dry polyherbal patches were evaluated for physicochemical properties by Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction, and a scanning electron microscope. They were studied for in vitro release and skin permeation of the marker active compound (E)-4-(3′,4′-dimethoxyphenyl)but-3-en-l-ol (compound D) using a modified Franz-type diffusion cell. The polyherbal patches made from PVA as a matrix layer were homogeneous, smooth, and compact relative to HPMC-containing polyherbal patches. The selected polyherbal patches made from PVA produced a release profile with an initial burst effect in which compound D release was 74.21 ± 6.13% within 8 h, but compound D could permeate the pig skin only 37.28 ± 5.52% and was highly accumulated in newborn pig skin at 35.90 ± 6.72%. The in vitro release and skin permeation kinetics of compound D were fitted to the Higuchi model. The polyherbal patches made from PVA could be suitably used for herbal medicine application.
引用
收藏
页码:2427 / 2436
页数:9
相关论文
共 50 条
  • [31] Formulation and in vitro evaluation of xanthan gum-based bilayered mucoadhesive buccal patches of zolmitriptan
    Shiledar, Rewathi R.
    Tagalpallewar, Amol A.
    Kokare, Chandrakant R.
    CARBOHYDRATE POLYMERS, 2014, 101 : 1234 - 1242
  • [32] Cellulose nanofibers from bamboo and their nanocomposites with polyvinyl alcohol: Preparation and characterization
    Han, Shenjie
    Yao, Qiufang
    Jin, Chunde
    Fan, Bitao
    Zheng, Huanhuan
    Sun, Qingfeng
    POLYMER COMPOSITES, 2018, 39 (08) : 2611 - 2619
  • [33] Preparation and characterization of hydrogels from polyvinyl alcohol and cellulose and their electroactive behavior
    Jayaramudu, Tippabattini
    Ko, Hyun-U
    Zhai, Lindong
    Li, Yaguang
    Kim, Jaehwan
    SOFT MATERIALS, 2017, 15 (01) : 64 - 72
  • [34] Development and characterization of biodegradable polyvinyl alcohol/carboxymethyl cellulose composite films
    Kapila, Karanjit
    Kirtania, Sushen
    JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION, 2025, : 2425 - 2437
  • [35] Formulation, Development and In-vitro evaluation of Anti-inflammatory Polyherbal Transdermal Patch
    Nighot, Manasi
    Dharkar, Nilima
    Patole, Vinita
    INTERNATIONAL JOURNAL OF AYURVEDIC MEDICINE, 2024, 15 (04) : 972 - 977
  • [36] Formulation, biopharmaceutical evaluation and in-vitro screening of polyherbal phytosomes for breast cancer therapy
    Govindaram, Lalitha K.
    Al Bratty, Mohammed
    Alhazmi, Hassan A.
    Kandasamy, Ruckmani
    Thangavel, Neelaveni
    Ibrahim, Angum M.
    Mariya, Gover Antoniraj
    Kumar, Ponnuchamy
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2022, 48 (10) : 552 - 565
  • [37] Formulation and evaluation of polyherbal anti-acne combination by using in-vitro model
    Prabhakar, Pranav Kumar
    Nath, Deepak
    Singh, Saurabh
    Mittal, Amit
    Baghel, Dileep Singh
    BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, 2020, 10 (01): : 4747 - 4751
  • [38] Evaluation of in vitro antioxidant and antimicrobial activity of polyherbal formulation of Thirikadugu chooranam and Parangipattai chooranam
    Sethumathi, P. P.
    Manjuparkavi, K.
    Lalitha, V
    Sivakumar, T.
    Menaka, M.
    Jayanthi, A.
    Kumar, B. Ashok
    ANNALS OF PHYTOMEDICINE-AN INTERNATIONAL JOURNAL, 2021, 10 (02): : 169 - 174
  • [39] Formulation design and in vitro ex vivo evaluation of transdermal patches of Cinnarizine
    Yamsani, Vamshi Vishnu
    Mudulaghar, Madan Kumar
    Afreen, Safoora
    Wajid, Syed
    Ravula, Shiva Kumar
    Babelghaith, Salmeen D.
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 30 (06) : 2075 - 2083
  • [40] Evaluation of Immunomodulatory Activity of a Polyherbal Formulation (Phytocee™) Using Ex Vivo and In Vitro Models
    Kumar, M. Naveen
    Murugan, Sasi Kumar
    Bethapudi, Bharathi
    Mundkinajeddu, Deepak
    PHARMACOGNOSY MAGAZINE, 2025, 21 (01) : 67 - 73