Understanding the Impacts of Surface Compositions on the In-Vitro Dissolution and Aerosolization of Co-Spray-Dried Composite Powder Formulations for Inhalation

被引:0
作者
Sharad Mangal
Rongkun Xu
Heejun Park
Dmitry Zemlyanov
Nivedita Shetty
Yu-Wei Lin
David Morton
Hak-Kim Chan
Jian Li
Qi Tony Zhou
机构
[1] Purdue University,Department of Industrial and Physical Pharmacy, College of Pharmacy
[2] Purdue University,Birck Nanotechnology Center
[3] Monash University,Monash Biomedicine Discovery Institute, Department of Microbiology
[4] Monash University,Drug Delivery, Dynamics & Deposition, Monash Institute of Pharmaceutical Sciences
[5] The University of Sydney,Advanced Drug Delivery Group, Faculty of Pharmacy
来源
Pharmaceutical Research | 2019年 / 36卷
关键词
aerosol performance; azithromycin; colistin; dissolution; dry powder inhaler; poorly water soluble drug; solubility; spray drying;
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  • [1] Mizgerd JP(2006)Lung infection--a public health priority PLoS Med 3 e76-295
  • [2] Hill AT(2000)Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitis Am J Med 109 288-1095
  • [3] Campbell EJ(2003)Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 167 1090-764
  • [4] Hill SL(2002)Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations Thorax 57 759-82
  • [5] Bayley DL(2015)Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead Adv Drug Deliv Rev 85 65-905
  • [6] Stockley RA(2009)Delivery of antibiotics to the respiratory tract: an update Expert Opin Drug Deliv 6 897-3294
  • [7] Wilkinson TM(2011)Population Pharmacokinetics of Colistin Methanesulfonate and Formed Colistin in Critically Ill Patients from a Multicenter Study Provide Dosing Suggestions for Various Categories of Patients Antimicrob Agents Chemother 55 3284-5095
  • [8] Patel IS(2013)Population pharmacokinetics of colistin methanesulfonate in rats: Achieving sustained lung concentrations of colistin for targeting respiratory infections Antimicrob Agents Chemother 57 5087-663
  • [9] Wilks M(2013)Inhaled antibiotics to treat lung infection Pharm Pat Anal 2 647-1155
  • [10] Donaldson GC(2010)Nebulized and intravenous colistin in experimental pneumonia caused by Pseudomonas aeruginosa Intensive Care Med 36 1147-1615