KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response

被引：0
|
作者：
Aaron A Goodarzi
Thomas Kurka
Penelope A Jeggo
机构：
[1] Genome Damage and Stability Centre,
[2] University of Sussex,undefined
来源：
Nature Structural & Molecular Biology | 2011年 / 18卷
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学科分类号：
摘要：
Heterochromatin factor KAP-1 is phosphorylated by ATM during the DNA damage response. Now the functional consequences of this modification are explored, revealing that the phosphorylated C-terminal region of KAP-1 perturbs the interaction between auto-SUMOylated KAP-1 and CHD3/Mi-2a, a component of the chromatin remodeler NuRD. This results in CHD3 dispersion from heterochromatin and allows DNA repair to proceed.
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页码：831 / 839
页数：8
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