Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1

被引：0

作者：

Mihir R. Atreya

Natalie Z. Cvijanovich

Julie C. Fitzgerald

Scott L. Weiss

Michael T. Bigham

Parag N. Jain

Adam J. Schwarz

Riad Lutfi

Jeffrey Nowak

Geoffrey L. Allen

Neal J. Thomas

Jocelyn R. Grunwell

Torrey Baines

Michael Quasney

Bereketeab Haileselassie

Matthew N. Alder

Patrick Lahni

Scarlett Ripberger

Adesuwa Ekunwe

Kyle R. Campbell

Keith R. Walley

Stephen W. Standage

机构：

[1] Cincinnati Children’s Hospital Medical Center,Division of Critical Care Medicine

[2] University of Cincinnati College of Medicine,Department of Pediatrics

[3] UCSF Benioff Children’s Hospital Oakland,Department of Medicine, Center for Heart Lung Innovation, St. Paul’s Hospital

[4] Children’s Hospital of Philadelphia,undefined

[5] Akron Children’s Hospital,undefined

[6] Texas Children’s Hospital and Baylor College of Medicine,undefined

[7] Children’s Hospital of Orange County,undefined

[8] Riley Hospital for Children,undefined

[9] Children’s Hospital and Clinics of Minnesota,undefined

[10] Children’s Mercy Hospital,undefined

[11] Penn State Hershey Children’s Hospital,undefined

[12] Children’s Healthcare of Atlanta at Egleston,undefined

[13] University of Florida Health Shands Children’s Hospital,undefined

[14] CS Mott Children’s Hospital at the University of Michigan,undefined

[15] Lucile Packard Children’s Hospital Stanford,undefined

[16] University of British Columbia,undefined

来源：

Critical Care | / 27卷

关键词：

Sepsis; Septic shock; Multiple organ dysfunction syndrome; PCSK9; LDLR; Genotype; Lipoproteins; Endothelium; Endothelial dysfunction; Biomarkers;

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摘要：

引用

共 3 条

[1] Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1
Atreya, Mihir R.
Cvijanovich, Natalie Z.
Fitzgerald, Julie C.
Weiss, Scott L.
Bigham, Michael T.
Jain, Parag N.
Schwarz, Adam J.
Lutfi, Riad
Nowak, Jeffrey
Allen, Geoffrey L.
Thomas, Neal J.
Grunwell, Jocelyn R.
Baines, Torrey
Quasney, Michael
Haileselassie, Bereketeab
Alder, Matthew N.
Lahni, Patrick
Ripberger, Scarlett
Ekunwe, Adesuwa
Campbell, Kyle R.
Walley, Keith R.
Standage, Stephen W.
CRITICAL CARE, 2023, 27 (01)
[2] Impact of PCSK9 loss-of-function genotype on 1-year mortality and recurrent infection in sepsis survivors
Genga, Kelly Roveran
Lo, Cody
Cirstea, Mihai S.
Leitao Filho, Fernando Sergio
Walley, Keith R.
Russell, James A.
Linder, Adam
Francis, Gordon A.
Boyd, John H.
EBIOMEDICINE, 2018, 38 : 257 - 264
[3] PCSK9 loss-of-function variants and risk of infection and sepsis in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort
Mitchell, Kellie A.
Moore, Justin Xavier
Rosenson, Robert S.
Irvin, Ryan
Guirgis, Faheem W.
Shapiro, Nathan
Safford, Monika
Wang, Henry E.
PLOS ONE, 2019, 14 (02):

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