Inhibitory study of two cephalosporins on E. coli by microcalorimetry

被引：0
作者：
L. N. Yang
Li Xian Sun
Fen Xu
J. Zhang
J. N. Zhao
Z. B. Zhao
C. G. Song
R. H. Wu
Riko Ozao
机构：
[1] Chinese Academy of Sciences,Materials and Thermochemistry Laboratory, Dalian Institute of Chemical Physics
[2] Zunyi Normal College,Department of Chemistry
[3] Liaoning Normal University,College of Chemistry and Chemical Engineering
[4] Chinese Academy of Sciences,Division of Biotechnology, Dalian Institute of Chemical Physics
[5] Dalian Institute of Drug Detection,undefined
[6] Sony Corporation,undefined
[7] Institute of Higher Education,undefined
来源：
Journal of Thermal Analysis and Calorimetry | 2010年 / 100卷
关键词：
Cefpiramide; Ceftizoxime sodium; Cephalosporins; DH5α; Metabolism; Inhibition; Microcalorimetry;
D O I：
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中图分类号：
学科分类号：
摘要：
The microcalorimetric method has been used to study the effects of cefpiramide and ceftizoxime sodium on the E. coli growth. The results revealed that these two cephalosporins may alter the metabolic way of the E. coli. Moreover, the lethal doses of cefpiramide and ceftizoxime sodium are 2.000 and 0.2000 μg mL−1, respectively. Combining with the relationships between growth rate constant (k), the maximum power output (Pm), the time corresponding to the maximum power output (tm) and cephalosporins concentration (C), one can draw the conclusion that the ceftizoxime sodium has a stronger inhibition effects on the growth of E. coli than that of cefpiramide and they both have the possibility to induce the drug fever.
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页码：589 / 592
页数：3
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