A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine Plus Buccal Midazolam for Non-painful Procedural Sedation in Children with Autism

被引：0

作者：

Bi Lian Li

Vivian Man-ying Yuen

Na Zhang

Huan Huan Zhang

Jun Xiang Huang

Si Yuan Yang

Jeffery W. Miller

Xing Rong Song

机构：

[1] Guangzhou Women and Children’s Medical Centre,Department of Anaesthesiology

[2] Guangzhou Medical University,Department of Anaesthesiology and Perioperative Medicine

[3] Hong Kong Children’s Hospital,Department of Psychiatry

[4] Guangzhou Women and Children’s Medical Centre and Guangzhou Medical University,Department of Anaesthesiology

[5] Cincinnati Children’s Hospital Medical Center,undefined

来源：

Journal of Autism and Developmental Disorders | 2019年 / 49卷

关键词：

Autism; Dexmedetomidine; Midazolam; Pediatric sedation;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Children with autism often need sedation for diagnostic procedures and they are often difficult to sedate. This prospective randomized double-blind control trial evaluates the efficacy and safety using intranasal dexmedetomidine with and without buccal midazolam for sedation in children with autism undergoing computerized tomography and/or auditory brainstem response test. The primary outcome is the proportion of children attaining satisfactory sedation. One hundred and thirty-six children received intranasal dexmedetomidine and 139 received intranasal dexmedetomidine with buccal midazolam for sedation. Combination of intranasal dexmedetomidine and buccal midazolam was associated with higher sedation success when compared to intranasal dexmedetomidine. Since intranasal and buccal sedatives required little cooperation this could be especially useful technique for children with autism or other behavioral conditions.

引用

页码：3798 / 3806

页数：8

共 85 条

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