Sustained release of amoxicillin from hydroxyapatite nanocomposite for bone infections

被引：81

作者：

Prasanna A.P.S. ^{[1
]}

Venkatasubbu G.D. ^{[2
]}

机构：

[1] Department of Physics, SRM Institute of Science and Technology, Kattankulathur, Kanchipuram, Tamil Nadu

[2] Department of Nanotechnology, SRM Institute of Science and Technology, Kattankulathur, Kanchipuram, 603 203, Tamil Nadu

来源：

Progress in Biomaterials | 2018年 / 7卷 / 4期

关键词：

Amoxicillin; Antimicrobial studies; Hydroxyapatite; Polyvinyl alcohol; Sodium alginate;

D O I：

10.1007/s40204-018-0103-4

中图分类号：

学科分类号：

摘要：

Hydroxyapatite (HAP) is the main constituent of human bone and teeth. Hydroxyapatite nanoparticles are used for the treatment of various bone infections. Nanohydroxyapatite is a biocompatible material. It is used as a drug carrier for drugs and biomolecules for various diseases. Hydroxyapatite nanoparticles are made into nanocomposite with sodium alginate and polyvinyl alcohol. This nanocomposite is used for the sustained release of drugs. It is characterized by various characterization techniques like XRD, FTIR, TEM, and Raman. Hydroxyapatite nanoparticles are coated initially with polyvinyl alcohol and then coated with sodium alginate. Amoxicillin is used as the model drug. Studies on the drug loading and drug release have been done. The release of the drug is sustained for about 30 days. Antimicrobial studies have shown good activity against pathogens. The zone of inhibition is found to be 18 mm for a concentration of 500 µg against Bacillus subtilis and 16 µg against Klebsiella pneumonia. © 2018, The Author(s).

引用

页码：289 / 296

页数：7

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