Developmental Neuroimaging in Pediatric Obsessive-Compulsive Disorder

被引：7
作者：
Liu Y. [1 ]
Bilek E.L. [1 ]
Fitzgerald K.D. [1 ]
机构：
[1] Department of Psychiatry, University of Michigan Medical School, 4250 Plymouth Road, Ann Arbor, 48109, MI
来源：
Current Behavioral Neuroscience Reports | 2016年 / 3卷 / 3期
关键词：
DTI; Executive function; fMRI; Pediatric OCD; Resting-state; Task-control network;
D O I：
10.1007/s40473-016-0086-1
中图分类号：
学科分类号：
摘要：
Purpose of review: This review examines emerging neuroimaging research in pediatric obsessive-compulsive disorder (OCD) and explores the possibility that developmentally sensitive mechanisms may underlie OCD across the lifespan. Recent findings: Diffusion tensor imaging (DTI) studies of pediatric OCD reveal abnormal structural connectivity within fronto-striato-thalamic circuity (FSTC). Resting-state functional magnetic resonance imaging (fMRI) studies further support atypical FSTC connectivity in young patients, but they also suggest altered connectivity within cortical networks for task control. Task-based fMRI studies show that hyperactivation and hypoactivation of task-control networks may depend on task difficulty in pediatric patients similar to recent findings in adults. Summary: This review suggests that atypical neurodevelopmental trajectories may underlie the emergence and early course of OCD. Abnormalities of structural and functional connectivity may vary with age, while functional engagement during task may vary with age and task complexity. Future research should combine DTI, resting-state fMRI, and task-based fMRI methods and incorporate longitudinal designs to reveal developmentally sensitive targets for intervention. © 2016, Springer International Publishing AG.
引用
收藏
页码：193 / 203
页数：10
相关论文
共 82 条
  • [1] Kessler R.C., Et al., Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication, Arch Gen Psychiatry, 62, 6, pp. 593-602, (2005)
  • [2] Pauls D.L., Et al., A family study of obsessive-compulsive disorder, Am J Psychiatry, 152, 1, pp. 76-84, (1995)
  • [3] Ruscio A.M., Et al., The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication, Mol Psychiatry, 15, 1, pp. 53-63, (2010)
  • [4] Stewart S.E., Et al., Long-term outcome of pediatric obsessive-compulsive disorder: a meta-analysis and qualitative review of the literature, Acta Psychiatr Scand, 110, 1, pp. 4-13, (2004)
  • [5] Menzies L., Et al., Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited, Neurosci Biobehav Rev, 32, 3, pp. 525-549, (2008)
  • [6] Alexander G.E., DeLong M.R., Strick P.L., Parallel organization of functionally segregated circuits linking basal ganglia and cortex, Annu Rev Neurosci, 9, pp. 357-381, (1986)
  • [7] Ridderinkhof K.R., Et al., The role of the medial frontal cortex in cognitive control, Science, 306, 5695, pp. 443-447, (2004)
  • [8] Haber S.N., Knutson B., The reward circuit: linking primate anatomy and human imaging, Neuropsychopharmacology, 35, 1, pp. 4-26, (2010)
  • [9] Baxter L.R., Et al., Brain mediation of obsessive-compulsive disorder symptoms: evidence from functional brain imaging studies in the human and nonhuman primate, Semin Clin Neuropsychiatry, 1, 1, pp. 32-47, (1996)
  • [10] Albin R.L., Young A.B., Penney J.B., The functional anatomy of basal ganglia disorders, Trends Neurosci, 12, 10, pp. 366-375, (1989)
123456789