Combined-modality therapy for esophageal and gastroesophageal junction cancers

被引：12

作者：

Yoon H.H. ^{[1
]}

Gibson M.K. ^{[1
]}

机构：

[1] Upper Aerodigestive Group, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231

来源：

Current Oncology Reports | 2007年 / 9卷 / 3期

关键词：

Esophageal Cancer; Esophageal Carcinoma; Preoperative Chemotherapy; Resectable Esophageal; Preoperative Chemoradiation;

D O I：

10.1007/s11912-007-0020-5

中图分类号：

学科分类号：

摘要：

The optimal management of locoregional esophageal cancer is controversial. Preoperative concomitant chemoradiotherapy (two courses of cisplatin and 5-fluorouracil plus 50 Gy of radiation) may provide benefit in survival and local control compared with surgery alone and is a reasonable alternative to surgery alone in stages IIB, III, and possibly stage IVa disease. This benefit is less clear in stages I and IIA, for which surgery alone is thus a reasonable option. Preoperative chemotherapy without radiation also provides a survival benefit compared with surgery alone, but data are insufficient to conclude it is superior to preoperative chemoradiotherapy. Control of distant disease remains a problem with preoperative chemotherapy and preoperative chemoradiotherapy. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：184 / 192

页数：8

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