Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia

被引：0
作者：
I Mathieson
M R Munafò
J Flint
机构：
[1] W,
[2] ellcome Trust Centre for Human Genetics,undefined
[3] University of Oxford,undefined
[4] School of Experimental Psychology,undefined
[5] University of Bristol,undefined
来源：
Molecular Psychiatry | 2012年 / 17卷
关键词：
association; case–control; DISC1; GWAS; meta-analysis; schizophrenia;
D O I：
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学科分类号：
摘要：
Several polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to be associated with schizophrenia. However, to date, there has been little effort to evaluate the evidence for association systematically. We carried out an imputation-driven meta-analysis, the most comprehensive to date, using data collected from 10 candidate gene studies and three genome-wide association studies containing a total of 11 626 cases and 15 237 controls. We tested 1241 single-nucleotide polymorphisms in total, and estimated that our power to detect an effect from a variant with minor allele frequency >5% was 99% for an odds ratio of 1.5 and 51% for an odds ratio of 1.1. We find no evidence that common variants at the DISC1 locus are associated with schizophrenia.
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页码：634 / 641
页数：7
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