Aminomethylation of Uracil and 6-Methyluracil by 3,4-dimethoxyphenylethylamine and Tetrahydroisoquinoline Derivatives

被引：0

作者：

Sh.N. Zhurakulov

Sh.B. Rakhimov

M. A. Kodirov

V. I. Vinogradova

Sh.Sh. Sagdullaev

机构：

[1] Academy of Sciences of the Republic of Uzbekistan,S. Yu. Yunusov Institute of the Chemistry of Plant Substances

[2] National University of Uzbekistan named after Mirzo Ulugbek,undefined

来源：

Chemistry of Natural Compounds | 2023年 / 59卷

关键词：

uracil; 6-methyluracil; 3,4-dimethoxyphenylethylamine; 1-aryltetrahydroisoquinolines; formalin; Mannich reaction;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The Mannich reactions of uracil and 6-methyluracil with homoveratrylamine and 1-aryltetrahydroisoquinolines in EtOH and dioxane were studied. 5-[(2-Hydroxymethyl)-4,5-dimethoxyphenylethylamino)methyl]-6-methylpyrimidine-2,4(1H, 3H)-dione was formed in EtOH in addition to the usual products (in dioxane).

引用

页码：331 / 335

页数：4

共 10 条

[1] Aminomethylation of Uracil and 6-Methyluracil by 3,4-dimethoxyphenylethylamine and Tetrahydroisoquinoline Derivatives
Zhurakulov, Sh. N.
Rakhimov, Sh. B.
Kodirov, M. A.
Vinogradova, V. I.
Sagdullaev, Sh. Sh.
CHEMISTRY OF NATURAL COMPOUNDS, 2023, 59 (02) : 331 - 335
[2] Synthesis of novel 1,2,3-triazolyl nucleoside analogues bearing uracil, 6-methyluracil, 3,6-dimethyluracil, thymine, and quinazoline-2,4-dione moieties
Andreeva, Olga V.
Belenok, Maya G.
Saifina, Liliya F.
Shulaeva, Marina M.
Dobrynin, Alexey B.
Sharipova, Radmila R.
Voloshina, Alexandra D.
Saifina, Alina F.
Gubaidullin, Aidar T.
Khairutdinov, Bulat I.
Zuev, Yuriy F.
Semenov, Vyacheslav E.
Kataev, Vladimir E.
TETRAHEDRON LETTERS, 2019, 60 (47)
[3] Cocrystals of 6-chlorouracil and 6-chloro-3-methyluracil: exploring their hydrogen-bond-based synthon motifs with several triazine and pyrimidine derivatives
Gerhardt, Valeska
Egert, Ernst
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS, 2015, 71 : 209 - 220
[4] Aminomethylation of 1,2,3,4-Tetrahydropyridine-6-thiolates: A Novel Approach to Synthesis of 3,7-Diazabicyclo[3.3.1]nonane Derivatives
V. V. Dotsenko
S. G. Krivokolysko
V. P. Litvinov
Chemistry of Heterocyclic Compounds, 2005, 41 (11) : 1428 - 1429
[5] Synthesis of Pyrido[1,2-a][1,3,5]Triazine Derivatives by Aminomethylation of 6-Amino-4-Aryl-2-Oxo-1,2-Dihydropyridine-3,5-Dicarbonitriles
Khrustaleva, A. N.
Frolov, K. A.
Dotsenko, V. V.
Dmitrienko, A. O.
Bushmarinov, I. S.
Krivokolysko, S. G.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2014, 50 (01) : 46 - 52
[6] Synthesis of Pyrido[1,2-a][1,3,5]Triazine Derivatives by Aminomethylation of 6-Amino-4-Aryl-2-Oxo-1,2-Dihydropyridine-3,5-Dicarbonitriles
A. N. Khrustaleva
K. A. Frolov
V. V. Dotsenko
A. O. Dmitrienko
I. S. Bushmarinov
S. G. Krivokolysko
Chemistry of Heterocyclic Compounds, 2014, 50 : 46 - 52
[7] Synthesis and anti-inflammatory activity evaluation of novel 3-alkyl-6-(4H-1,2,4-triazol-4-yl)-3,4-dihydro-2H-benzo[e][1,3]oxazine derivatives
Yan-Fei Li
Hong-Jian Zhang
Zhe-Shan Quan
Medicinal Chemistry Research, 2016, 25 : 2280 - 2288
[8] Synthesis and anti-inflammatory activity evaluation of novel 3-alkyl-6-(4H-1,2,4-triazol-4-yl)-3,4-dihydro-2H-benzo[e][1,3]oxazine derivatives
Li, Yan-Fei
Zhang, Hong-Jian
Quan, Zhe-Shan
MEDICINAL CHEMISTRY RESEARCH, 2016, 25 (10) : 2280 - 2288
[9] Aminomethylation of N-methylmorpholinium 6-amino-4-aryl-3,5-dicyano-1,4-dihydropyridine-2-selenolates as an approach to the preparation of 3,5,7,11-tetraazatricyclo[7.3.1.02,7]tridec-2-ene-8-selenone derivatives
Frolov, K. A.
Dotsenko, V. V.
Krivokolysko, S. G.
RUSSIAN CHEMICAL BULLETIN, 2013, 62 (06) : 1401 - 1404
[10] Aminomethylation of N-methylmorpholinium 6-amino-4-aryl-3,5-dicyano-1,4-dihydropyridine-2-selenolates as an approach to the preparation of 3,5,7,11-tetraazatricyclo[7.3.1.02,7]tridec-2-ene-8-selenone derivatives
K. A. Frolov
V. V. Dotsenko
S. G. Krivokolysko
Russian Chemical Bulletin, 2013, 62 : 1401 - 1404

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