Synthesis and characterization of novel metabotropic glutamate receptor 2/3 (mGluR2/3) positive allosteric modulator (PAM)

被引:0
|
作者
Piotr Brański
Jakub Staroń
Ryszard Bugno
Joanna Wierońska
Andrzej Bojarski
Grzegorz Burnat
Agnieszka Pałucha-Poniewiera
Andrzej Pilc
机构
[1] Polish Academy of Science,Department of Neurobiology
[2] Polish Academy of Science,Department of Medicinal Chemistry, Institute of Pharmacology
关键词
D O I
10.1016/S1734-1140(11)70547-3
中图分类号
学科分类号
摘要
引用
收藏
页码:577 / 577
相关论文
共 50 条
  • [1] Synthesis and characterization of novel metabotropic glutamate receptor 2/3 (mGluR2/3) positive allosteric modulator (PAM)
    Branski, Piotr
    Staron, Jakub
    Bugno, Ryszard
    Wieronska, Joanna
    Bojarski, Andrzej
    Burnat, Grzegorz
    Palucha-Poniewiera, Agnieszka
    Pilc, Andrzej
    PHARMACOLOGICAL REPORTS, 2011, 63 (02) : 577 - 577
  • [2] Positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (mGluR2)
    Rudd, MT
    McCauley, JA
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2005, 5 (09) : 869 - 884
  • [3] Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia
    Olivares-Berjaga, David
    Martinez-Pinteno, Albert
    Rodriguez, Natalia
    Mas, Sergi
    Moren, Constanza
    Parellada, Eduard
    Gasso, Patricia
    TRANSLATIONAL PSYCHIATRY, 2025, 15 (01):
  • [4] Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)
    Williams, Richard
    Johnson, Kari A.
    Gentry, Patrick R.
    Niswender, Colleen M.
    Weaver, Charles D.
    Conn, P. Jeffrey
    Lindsley, Craig W.
    Hopkins, Corey R.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (17) : 4967 - 4970
  • [5] Design and Synthesis of an Orally Active Metabotropic Glutamate Receptor Subtype-2 (mGluR2) Positive Allosteric Modulator (PAM) That Decreases Cocaine Self-Administration in Rats
    Dhanya, Raveendra-Panickai
    Sidique, Shyama
    Sheffler, Douglas J.
    Nickols, Hilary Highfield
    Herath, Ananda
    Yang, Li
    Dahl, Russell
    Ardecky, Robert
    Semenova, Svetlana
    Markou, Athina
    Conn, P. Jeffrey
    Cosford, Nicholas D. P.
    JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (01) : 342 - 353
  • [6] Discovery of dihydropyrrolopyrazinone derivatives as metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulators (PAMs)
    Tsuda, Yusuke
    Fukaya, Takayuki
    Masuda, Takahiro
    Sugishita, Aiko
    Sumitomo, Masako
    Kitamura, Atsushi
    Nishimura, Naohiro
    Masumoto, Shuji
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
  • [7] Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site
    Rowe, Blake A.
    Schaffhauser, Herve
    Morales, Sylvia
    Lubbers, Laura S.
    Bonnefous, Celine
    Kamenecka, Theodore M.
    McQuiston, Jeffrey
    Daggett, Lorrie P.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2008, 326 (01): : 240 - 251
  • [8] Design, synthesis, and evaluation of novel metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulators (PAMs): Refinement of SAR
    Sidique, Shyama
    Sheffler, Douglas
    Nickols, Hilary Highfield
    D'Souza, Manoranjan
    Yang, Li
    Dahl, Russell
    Semenova, Svetlana
    Markou, Athina
    Conn, Jeffrey
    Cosford, Nicholas D. P.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [9] Chemical Switch of a Metabotropic Glutamate Receptor 2 Silent Allosteric Modulator into Dual Metabotropic Glutamate Receptor 2/3 Negative/Positive Allosteric Modulators
    Schann, Stephan
    Mayer, Stanislas
    Franchet, Christel
    Frauli, Melanie
    Steinberg, Edith
    Thomas, Mireille
    Baron, Luc
    Neuville, Pascal
    JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (24) : 8775 - 8779
  • [10] Substituted acetophenones as selective and potent allosteric potentiators of the metabotropic glutamate receptor 2 (mGluR2)
    Pinkerton, AB
    Cube, RV
    Hutchinson, JH
    Gardner, MF
    James, JK
    Rowe, BA
    Schaffhauser, H
    Rodriguez, DE
    Campbell, UC
    Baccei, CS
    Lorrain, DS
    Daggett, L
    Vernier, JM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U111 - U112