Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock

被引：0

作者：

Subrina Jesmin

Satoshi Gando

Takeshi Wada

Mineji Hayakawa

Atsushi Sawamura

机构：

[1] Hokkaido University Graduate School of Medicine,Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine

来源：

Journal of Intensive Care | / 4卷 / 1期

关键词：

Trauma; Coagulopathy; Disseminated intravascular coagulation (DIC); Activated protein C;

D O I：

10.1186/s40560-015-0123-2

中图分类号：

学科分类号：

摘要：

We hypothesized that activated protein C does not increase in disseminated intravascular coagulation (DIC) after trauma and that the same is true for acute coagulopathy of trauma-shock (ACOTS). Activated protein C levels were prospectively measured in 57 trauma patients: 30 with DIC and 27 without DIC. Normal to more decreased activated protein C levels were observed in DIC patients than in the controls and non-DIC patients. The activated protein C levels in ACOTS patients were similar to those in DIC patients. In conclusion, activated protein C does not increase in either DIC or ACOTS in the early phase of trauma.

引用

共 33 条

[1] Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock
Jesmin, Subrina
Gando, Satoshi
Wada, Takeshi
Hayakawa, Mineji
Sawamura, Atsushi
JOURNAL OF INTENSIVE CARE, 2016, 4
[2] Differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS)
Gando, S.
Wada, H.
Thachil, J.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2013, 11 (05) : 826 - 835
[3] Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study
Pär I Johansson
Anne Marie Sørensen
Anders Perner
Karen Lise Welling
Michael Wanscher
Claus F Larsen
Sisse R Ostrowski
Critical Care, 15
[4] Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study
Johansson, Par I.
Sorensen, Anne Marie
Perner, Anders
Welling, Karen Lise
Wanscher, Michael
Larsen, Claus F.
Ostrowski, Sisse R.
CRITICAL CARE, 2011, 15 (06): : R272
[5] Normal prothrombinase activity, increased systemic thrombin activity, and lower antithrombin levels in patients with disseminated intravascular coagulation at an early phase of trauma: Comparison with acute coagulopathy of trauma-shock
Yanagida, Yuichiro
Gando, Satoshi
Sawamura, Atsushi
Hayakawa, Mineji
Uegaki, Shinji
Kubota, Nobuhiko
Homma, Taeko
Ono, Yuichi
Honma, Yoshinori
Wada, Takeshi
Jesmin, Subrina
SURGERY, 2013, 154 (01) : 48 - 57
[6] Activated protein C plays no major roles in the inhibition of coagulation or increased fibrinolysis in acute coagulopathy of trauma-shock: a systematic review
Gando, Satoshi
Mayumi, Toshihiko
Ukai, Tomohiko
THROMBOSIS JOURNAL, 2018, 16
[7] Activated protein C plays no major roles in the inhibition of coagulation or increased fibrinolysis in acute coagulopathy of trauma-shock: a systematic review
Satoshi Gando
Toshihiko Mayumi
Tomohiko Ukai
Thrombosis Journal, 16
[8] Research progress of acute coagulopathy of trauma-shock
Li, Baiqiang
Sun, Haichen
CHINESE JOURNAL OF TRAUMATOLOGY, 2015, 18 (02) : 95 - 97
[9] Research progress of acute coagulopathy of trauma-shock
Li Baiqiang
Sun Haichen
中华创伤杂志英文版, 2015, 18 (02) : 95 - 97
[10] Disseminated Intravascular Coagulation (DIC) at an Early Phase of Trauma Continuously Proceeds to DIC at a Late Phase of Trauma
Murakami, Hiromoto
Gando, Satoshi
Hayakawa, Mineji
Sawamura, Atsushi
Sugano, Masahiro
Kubota, Nobuhiko
Uegaki, Shinji
Jesmin, Subrina
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2012, 18 (04) : 364 - 369

← 1 2 3 4 →