Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility

被引:0
作者
Nergiz Dogan
Weisheng Wu
Christapher S Morrissey
Kuan-Bei Chen
Aaron Stonestrom
Maria Long
Cheryl A Keller
Yong Cheng
Deepti Jain
Axel Visel
Len A Pennacchio
Mitchell J Weiss
Gerd A Blobel
Ross C Hardison
机构
[1] The Pennsylvania State University,Center for Comparative Genomics and Bioinformatics, Department of Biochemistry and Molecular Biology
[2] University of Michigan,Bioinformatics Core, Department of Computational Medicine and Bioinformatics
[3] The Children’s Hospital of Philadelphia,Division of Hematology
[4] Perelman School of Medicine at the University of Pennsylvania,Department of Genetics, Mail Stop
[5] Stanford University,5120
[6] Lawrence Berkeley National Laboratory,Genomics Division
[7] DOE Joint Genome Institute,Department of Hematology
[8] St Jude Children’s Research Hospital,undefined
来源
Epigenetics & Chromatin | / 8卷
关键词
Functional genomics; Gene regulation; TAL1; GATA1; Histone modifications; Enhancer assay;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 512 条
  • [1] Hardison RC(2012)Genomic approaches towards finding cis-regulatory modules in animals Nat Rev Genet 13 469-83
  • [2] Taylor J(2008)Evaluation of phylogenetic footprint discovery for predicting bacterial cis-regulatory elements and revealing their evolution BMC Bioinf 9 37-72
  • [3] Janky R(2000)Conserved noncoding sequences are reliable guides to regulatory elements Trends Genet 16 369-10
  • [4] van Helden J(2002)Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes Science 297 1301-502
  • [5] Hardison RC(2006)In vivo enhancer analysis of human conserved non-coding sequences Nature 444 499-8
  • [6] Aparicio S(2005)Highly conserved non-coding sequences are associated with vertebrate development PLoS Biol 3 e7-10
  • [7] Chapman J(2009)ChIP-seq accurately predicts tissue-specific activity of enhancers Nature 457 854-40
  • [8] Stupka E(2010)ChIP-seq identification of weakly conserved heart enhancers Nat Genet 42 806-64
  • [9] Putnam N(2010)Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding Science 328 1036-604
  • [10] Chia JM(2014)A comparative encyclopedia of DNA elements in the mouse genome Nature 515 355-92