FeCl3·6H2O-catalyzed synthesis of β-ketothioesters from chain α-oxo ketene dithioactals

被引：0
|
作者：
Hui Zhao
Quanping Diao
Haifeng Yu
Tiechun Li
Peiqiu Liao
Dongyan Hou
机构：
[1] Anshan Normal University,School of Chemistry and Life Science
[2] Northeast Normal University,Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry
来源：
Chemical Research in Chinese Universities | 2017年 / 33卷
关键词：
Iron(III) chloride; Thioester; Ketene dithioacetal; Hydrolysis; Friedel-Crafts alkylation;
D O I：
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学科分类号：
摘要：
A FeCl3·6H2O-catalyzed synthesis of β-ketothioesters from the hydrolysis reaction of chain α-oxoketene dithioacetals was carried out. Subsequently, we explored the FeCl3·6H2O-catalyzed Friedel-Crafts alkylation of the synthesized β-ketothioesters with alcohols in CH3CN at 25 °C, affording the desired α-alkylated β-ketothioesters in excellent yields. Wide scope of the substrates, use of inexpensive reagents, high yields under mild reaction conditions are notable features of these reactions.
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页码：746 / 752
页数：6
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