Wig-1, a novel regulator of N-Myc mRNA and N-Myc-driven tumor growth

被引：0
作者：
A Vilborg
C Bersani
M Wickström
L Segerström
P Kogner
K G Wiman
机构：
[1] Karolinska Institutet,Department of Oncology
[2] Karolinska Institutet,Pathology
[3] 3Current address: Department of Molecular Biophysics and Biochemistry,Department of Women's and Children's Health
[4] BCMM 133,undefined
[5] Yale University,undefined
[6] 06510 New Haven,undefined
[7] CT,undefined
[8] USA,undefined
来源：
Cell Death & Disease | 2012年 / 3卷
关键词：
Wig-1; N-Myc; p53; mRNA regulation; AU-rich elements;
D O I：
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中图分类号：
学科分类号：
摘要：
Wig-1 is a transcriptional target of the p53 tumor suppressor and encodes an mRNA stability-regulating protein. We show here that Wig-1 knockdown causes a dramatic inhibition of N-Myc expression and triggers differentiation in neuroblastoma cells carrying amplified N-Myc. Transient Wig-1 knockdown significantly delays development of N-Myc-driven tumors in mice. We also show that N-Myc expression is induced upon moderate p53-activating stress, suggesting a role of the p53-Wig-1-N-Myc axis in promoting cell cycle re-entry upon p53-induced cell cycle arrest and DNA repair. Moreover, our findings raise possibilities for the improved treatment of poor prognosis neuroblastomas that carry amplified N-Myc.
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页码：e298 / e298
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