The immunotropic activity of lupane and oleanane 2,3-seco-triterpenoids

被引：0

作者：

L. V. Anikina

I. A. Tolmacheva

Yu. B. Vikharev

V. V. Grishko

机构：

[1] Russian Academy of Sciences,Institute of Technical Chemistry, Ural Division

来源：

Russian Journal of Bioorganic Chemistry | 2010年 / 36卷

关键词：

2,3-seco-triterpenoids; betulin; betulonic acid; allobetulon; immunotropic action; structure-activity relationship;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The immunotropic effect of the 2,3-seco derivatives of allobetulon, betulonic acid, and the methyl ester of betulonic acid were studied. It was found that the highest activity is shown by compounds with an oleanane fragment. The presence of a free C28-carboxyl group enhances the activity of lupane 2,3-seco derivatives. A significant contribution to the development of the immune response is introduced by a functional group at the C3 atom in the A ring—the C3-carboxy derivatives intensify the processes of antibody production and alter the number and ratio of leukocyte forms. It is shown that 2,3-seco-1-cyano-19β,28-epoxy-18α-olean-3-oic acid stimulates humoral immunity with a positive influence on hematopoiesis.

引用

页码：240 / 244

页数：4

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