Mesenchymal stem cell-derived extracellular vesicles in therapy against fibrotic diseases

被引：0
作者：
Yuling Huang
Lina Yang
机构：
[1] The First Affiliated Hospital of China Medical University,Departments of Geriatrics
来源：
Stem Cell Research & Therapy | / 12卷
关键词：
Fibrosis; Mesenchymal stem cells; Extracellular vesicles;
D O I：
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学科分类号：
摘要：
Fibrosis is likely to occur in many tissues and organs to induce cicatrisation and dysfunction. The therapeutic regimens for delaying and even reversing fibrosis are quite limited at present. In nearly a decade, mesenchymal stem cells (MSCs) have been widely acknowledged as useful in treating fibrotic diseases in preclinical and clinical trials. Further preclinical studies indicated that the effects of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are probably superior to that of MSCs. At present, MSC-EVs have attracted much attention in treating fibrosis of lung, liver, kidney, skin, and heart. By contrast, a significant knowledge-gap remains in treating fibrosis of other tissues and organs (including uterus, gastrointestinal tract, and peritoneum) with the aid of MSC-EVs. This review summarises the preclinical research status of MSC-EVs in treating fibrotic diseases and proposes solutions to existing problems, which contribute to further clinical research on the treatment of fibrotic diseases with MSC-EVs in the future.
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