Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention

被引：0

作者：

Ekta Shirbhate

Jaiprakash Pandey

Vijay K. Patel

Mehnaz Kamal

Talha Jawaid

Bapi Gorain

Prashant Kesharwani

Harish Rajak

机构：

[1] Institute of Pharmaceutical Sciences,Department of Pharmaceutical Chemistry, College of Pharmacy

[2] Guru Ghasidas University (A Central University),Department of Pharmacology, College of Medicine

[3] Prince Sattam Bin Abdulaziz University,School of Pharmacy, Faculty of Health and Medical Sciences

[4] Al Imam Bin Saud Islamic University,undefined

[5] Taylor’s University,undefined

[6] Department of Pharmaceutics,undefined

[7] School of Pharmaceutical Education and Research,undefined

来源：

Pharmacological Reports | 2021年 / 73卷

关键词：

Acute lung injury; Acute respiratory distress syndrome; Angiotensin-converting enzyme-2; COVID-19; SARS-CoV-2; rhACE2;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular system disorders. The recent pandemic of COVID-19 has attracted the attention of numerous researchers on ACE2 receptors, where the causative viral particle, SARS-CoV-2, is established to exploit these receptors for permitting their entry into the human cells. Therefore, studies on the molecular origin and pathophysiology of the cell response in correlation to the role of ACE2 receptors to these viruses are bringing novel theories. The varying level of manifestation and importance of ACE proteins, underlying irregularities and disorders, intake of specific medications, and persistence of assured genomic variants at the ACE genes are potential questions raising nowadays while observing the marked alteration in response to the SARS-CoV-2-infected patients. Therefore, the present review has focused on several raised opinions associated with the role of the ACE2 receptor and its impact on COVID-19 pathogenesis.

引用

页码：1539 / 1550

页数：11

共 402 条

[1] Dhama K(2020)COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics Hum Vaccines Immunother 16 1232-1238
[2] Sharun K(2020)Fighting strategies against the novel coronavirus pandemic: impact on global economy Front Publ Health 8 800-544
[3] Tiwari R(2020)The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming its SARS-CoV-2 Nat Microbiol 5 536-20
[4] Dadar M(2020)The pivotal link between ACE2 deficiency and SARS-CoV-2 infection Eur J Intern Med 76 14-590
[5] Malik YS(2020)SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Cell 181 280-294
[6] Singh KP(2020)In-line treatments and clinical initiatives to fight against COVID-19 outbreak Respir Med 46 586-1326
[7] Gorain B(2020)Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target Intensive Care Med 25 291-759
[8] Choudhury H(2004)ACE2: From vasopeptidase to SARS virus receptor Trends Pharmacol Sci 118 1313-66
[9] Molugulu N(2016)Role of the ACE2/angiotensin 1–7 axis of the renin-angiotensin system in heart failure Circ Res 202 756-105
[10] Athawale RB(2020)Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov Am J Respir Crit Care Med 25 59-4

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